An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T
© 2020, The Author(s). Metabolic imaging of the human brain by in-vivo magnetic resonance spectroscopic imaging (MRSI) can non-invasively probe neurochemistry in healthy and disease conditions. MRSI at ultra-high field (≥ 7 T) provides increased sensitivity for fast high-resolution metabolic imaging...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/134111 |
| _version_ | 1826209409260322816 |
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| author | Esmaeili, Morteza Stockmann, Jason Strasser, Bernhard Arango, Nicolas Thapa, Bijaya Wang, Zhe van der Kouwe, Andre Dietrich, Jorg Cahill, Daniel P Batchelor, Tracy T White, Jacob Adalsteinsson, Elfar Wald, Lawrence Andronesi, Ovidiu C |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Esmaeili, Morteza Stockmann, Jason Strasser, Bernhard Arango, Nicolas Thapa, Bijaya Wang, Zhe van der Kouwe, Andre Dietrich, Jorg Cahill, Daniel P Batchelor, Tracy T White, Jacob Adalsteinsson, Elfar Wald, Lawrence Andronesi, Ovidiu C |
| author_sort | Esmaeili, Morteza |
| collection | MIT |
| description | © 2020, The Author(s). Metabolic imaging of the human brain by in-vivo magnetic resonance spectroscopic imaging (MRSI) can non-invasively probe neurochemistry in healthy and disease conditions. MRSI at ultra-high field (≥ 7 T) provides increased sensitivity for fast high-resolution metabolic imaging, but comes with technical challenges due to non-uniform B0 field. Here, we show that an integrated RF-receive/B0-shim (AC/DC) array coil can be used to mitigate 7 T B0 inhomogeneity, which improves spectral quality and metabolite quantification over a whole-brain slab. Our results from simulations, phantoms, healthy and brain tumor human subjects indicate improvements of global B0 homogeneity by 55%, narrower spectral linewidth by 29%, higher signal-to-noise ratio by 31%, more precise metabolite quantification by 22%, and an increase by 21% of the brain volume that can be reliably analyzed. AC/DC shimming provide the highest correlation (R2 = 0.98, P = 0.001) with ground-truth values for metabolite concentration. Clinical translation of AC/DC and MRSI is demonstrated in a patient with mutant-IDH1 glioma where it enables imaging of D-2-hydroxyglutarate oncometabolite with a 2.8-fold increase in contrast-to-noise ratio at higher resolution and more brain coverage compared to previous 7 T studies. Hence, AC/DC technology may help ultra-high field MRSI become more feasible to take advantage of higher signal/contrast-to-noise in clinical applications. |
| first_indexed | 2024-09-23T14:22:22Z |
| format | Article |
| id | mit-1721.1/134111 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:22:22Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1341112023-10-06T20:35:31Z An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T Esmaeili, Morteza Stockmann, Jason Strasser, Bernhard Arango, Nicolas Thapa, Bijaya Wang, Zhe van der Kouwe, Andre Dietrich, Jorg Cahill, Daniel P Batchelor, Tracy T White, Jacob Adalsteinsson, Elfar Wald, Lawrence Andronesi, Ovidiu C Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science © 2020, The Author(s). Metabolic imaging of the human brain by in-vivo magnetic resonance spectroscopic imaging (MRSI) can non-invasively probe neurochemistry in healthy and disease conditions. MRSI at ultra-high field (≥ 7 T) provides increased sensitivity for fast high-resolution metabolic imaging, but comes with technical challenges due to non-uniform B0 field. Here, we show that an integrated RF-receive/B0-shim (AC/DC) array coil can be used to mitigate 7 T B0 inhomogeneity, which improves spectral quality and metabolite quantification over a whole-brain slab. Our results from simulations, phantoms, healthy and brain tumor human subjects indicate improvements of global B0 homogeneity by 55%, narrower spectral linewidth by 29%, higher signal-to-noise ratio by 31%, more precise metabolite quantification by 22%, and an increase by 21% of the brain volume that can be reliably analyzed. AC/DC shimming provide the highest correlation (R2 = 0.98, P = 0.001) with ground-truth values for metabolite concentration. Clinical translation of AC/DC and MRSI is demonstrated in a patient with mutant-IDH1 glioma where it enables imaging of D-2-hydroxyglutarate oncometabolite with a 2.8-fold increase in contrast-to-noise ratio at higher resolution and more brain coverage compared to previous 7 T studies. Hence, AC/DC technology may help ultra-high field MRSI become more feasible to take advantage of higher signal/contrast-to-noise in clinical applications. 2021-10-27T19:58:09Z 2021-10-27T19:58:09Z 2020 2020-11-20T18:16:45Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134111 en 10.1038/s41598-020-71623-5 Scientific Reports Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Scientific Reports |
| spellingShingle | Esmaeili, Morteza Stockmann, Jason Strasser, Bernhard Arango, Nicolas Thapa, Bijaya Wang, Zhe van der Kouwe, Andre Dietrich, Jorg Cahill, Daniel P Batchelor, Tracy T White, Jacob Adalsteinsson, Elfar Wald, Lawrence Andronesi, Ovidiu C An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T |
| title | An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T |
| title_full | An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T |
| title_fullStr | An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T |
| title_full_unstemmed | An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T |
| title_short | An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T |
| title_sort | integrated rf receive b0 shim array coil boosts performance of whole brain mr spectroscopic imaging at 7 t |
| url | https://hdl.handle.net/1721.1/134111 |
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