Fabrication of fillable microparticles and other complex 3D microstructures
© 2017, American Association for the Advancement of Science. All rights reserved. Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques use...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/134190 |
| _version_ | 1811096972624396288 |
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| author | McHugh, Kevin J Nguyen, Thanh D Linehan, Allison R Yang, David Behrens, Adam M Rose, Sviatlana Tochka, Zachary L Tzeng, Stephany Y Norman, James J Anselmo, Aaron C Xu, Xian Tomasic, Stephanie Taylor, Matthew A Lu, Jennifer Guarecuco, Rohiverth Langer, Robert Jaklenec, Ana |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT McHugh, Kevin J Nguyen, Thanh D Linehan, Allison R Yang, David Behrens, Adam M Rose, Sviatlana Tochka, Zachary L Tzeng, Stephany Y Norman, James J Anselmo, Aaron C Xu, Xian Tomasic, Stephanie Taylor, Matthew A Lu, Jennifer Guarecuco, Rohiverth Langer, Robert Jaklenec, Ana |
| author_sort | McHugh, Kevin J |
| collection | MIT |
| description | © 2017, American Association for the Advancement of Science. All rights reserved. Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing. SEAL allows us to generate microstructures with complex geometry at high resolution, produce fully enclosed internal cavities containing a solid or liquid, and use potentially any thermoplastic material without processing additives. |
| first_indexed | 2024-09-23T16:52:19Z |
| format | Article |
| id | mit-1721.1/134190 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:52:19Z |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1341902023-02-17T19:43:04Z Fabrication of fillable microparticles and other complex 3D microstructures McHugh, Kevin J Nguyen, Thanh D Linehan, Allison R Yang, David Behrens, Adam M Rose, Sviatlana Tochka, Zachary L Tzeng, Stephany Y Norman, James J Anselmo, Aaron C Xu, Xian Tomasic, Stephanie Taylor, Matthew A Lu, Jennifer Guarecuco, Rohiverth Langer, Robert Jaklenec, Ana Koch Institute for Integrative Cancer Research at MIT © 2017, American Association for the Advancement of Science. All rights reserved. Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing. SEAL allows us to generate microstructures with complex geometry at high resolution, produce fully enclosed internal cavities containing a solid or liquid, and use potentially any thermoplastic material without processing additives. 2021-10-27T19:58:34Z 2021-10-27T19:58:34Z 2017 2021-06-14T14:04:21Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134190 en 10.1126/SCIENCE.AAF7447 Science Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Science |
| spellingShingle | McHugh, Kevin J Nguyen, Thanh D Linehan, Allison R Yang, David Behrens, Adam M Rose, Sviatlana Tochka, Zachary L Tzeng, Stephany Y Norman, James J Anselmo, Aaron C Xu, Xian Tomasic, Stephanie Taylor, Matthew A Lu, Jennifer Guarecuco, Rohiverth Langer, Robert Jaklenec, Ana Fabrication of fillable microparticles and other complex 3D microstructures |
| title | Fabrication of fillable microparticles and other complex 3D microstructures |
| title_full | Fabrication of fillable microparticles and other complex 3D microstructures |
| title_fullStr | Fabrication of fillable microparticles and other complex 3D microstructures |
| title_full_unstemmed | Fabrication of fillable microparticles and other complex 3D microstructures |
| title_short | Fabrication of fillable microparticles and other complex 3D microstructures |
| title_sort | fabrication of fillable microparticles and other complex 3d microstructures |
| url | https://hdl.handle.net/1721.1/134190 |
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