A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects
Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well withinwet and highly dynamic environments within the body. This is especially relevant tominimally invasive surgery that is increasingly performed to reduce postoperative complication...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2021
|
| Online Access: | https://hdl.handle.net/1721.1/134265 |
| _version_ | 1826192181007745024 |
|---|---|
| author | Lang, N Pereira, MJ Lee, Y Friehs, I Vasilyev, NV Feins, EN Ablasser, K O'Cearbhaill, ED Xu, C Fabozzo, A Padera, R Wasserman, S Freudenthal, F Ferreira, LS Langer, R Karp, JM del Nido, PJ |
| author_facet | Lang, N Pereira, MJ Lee, Y Friehs, I Vasilyev, NV Feins, EN Ablasser, K O'Cearbhaill, ED Xu, C Fabozzo, A Padera, R Wasserman, S Freudenthal, F Ferreira, LS Langer, R Karp, JM del Nido, PJ |
| author_sort | Lang, N |
| collection | MIT |
| description | Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well withinwet and highly dynamic environments within the body. This is especially relevant tominimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis. |
| first_indexed | 2024-09-23T09:07:29Z |
| format | Article |
| id | mit-1721.1/134265 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:07:29Z |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1342652022-03-31T14:31:25Z A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects Lang, N Pereira, MJ Lee, Y Friehs, I Vasilyev, NV Feins, EN Ablasser, K O'Cearbhaill, ED Xu, C Fabozzo, A Padera, R Wasserman, S Freudenthal, F Ferreira, LS Langer, R Karp, JM del Nido, PJ Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well withinwet and highly dynamic environments within the body. This is especially relevant tominimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis. 2021-10-27T20:04:14Z 2021-10-27T20:04:14Z 2014 2019-09-05T16:15:08Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134265 Lang, N., et al. "A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects." Science Translational Medicine 6 218 (2014). en 10.1126/SCITRANSLMED.3006557 Science Translational Medicine Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Lang, N Pereira, MJ Lee, Y Friehs, I Vasilyev, NV Feins, EN Ablasser, K O'Cearbhaill, ED Xu, C Fabozzo, A Padera, R Wasserman, S Freudenthal, F Ferreira, LS Langer, R Karp, JM del Nido, PJ A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects |
| title | A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects |
| title_full | A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects |
| title_fullStr | A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects |
| title_full_unstemmed | A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects |
| title_short | A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects |
| title_sort | blood resistant surgical glue for minimally invasive repair of vessels and heart defects |
| url | https://hdl.handle.net/1721.1/134265 |
| work_keys_str_mv | AT langn abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT pereiramj abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT leey abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT friehsi abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT vasilyevnv abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT feinsen abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT ablasserk abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT ocearbhailled abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT xuc abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT fabozzoa abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT paderar abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT wassermans abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT freudenthalf abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT ferreirals abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT langerr abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT karpjm abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT delnidopj abloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT langn bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT pereiramj bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT leey bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT friehsi bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT vasilyevnv bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT feinsen bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT ablasserk bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT ocearbhailled bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT xuc bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT fabozzoa bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT paderar bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT wassermans bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT freudenthalf bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT ferreirals bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT langerr bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT karpjm bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects AT delnidopj bloodresistantsurgicalglueforminimallyinvasiverepairofvesselsandheartdefects |