Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
© 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury tar...
Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Elsevier BV
2021
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Online Access: | https://hdl.handle.net/1721.1/134416 |
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author | Sheppard, Hadley E Dall’Agnese, Alessandra Park, Woojun D Shamim, M Hamza Dubrulle, Julien Johnson, Hannah L Stossi, Fabio Cogswell, Patricia Sommer, Josh Levy, Joan Sharifnia, Tanaz Wawer, Mathias J Nabet, Behnam Gray, Nathanael S Clemons, Paul A Schreiber, Stuart L Workman, Paul Young, Richard A Lin, Charles Y |
author2 | Massachusetts Institute of Technology. Department of Biology |
author_facet | Massachusetts Institute of Technology. Department of Biology Sheppard, Hadley E Dall’Agnese, Alessandra Park, Woojun D Shamim, M Hamza Dubrulle, Julien Johnson, Hannah L Stossi, Fabio Cogswell, Patricia Sommer, Josh Levy, Joan Sharifnia, Tanaz Wawer, Mathias J Nabet, Behnam Gray, Nathanael S Clemons, Paul A Schreiber, Stuart L Workman, Paul Young, Richard A Lin, Charles Y |
author_sort | Sheppard, Hadley E |
collection | MIT |
description | © 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury targeting is a promising therapeutic strategy. |
first_indexed | 2024-09-23T15:46:04Z |
format | Article |
id | mit-1721.1/134416 |
institution | Massachusetts Institute of Technology |
language | English |
last_indexed | 2024-09-23T15:46:04Z |
publishDate | 2021 |
publisher | Elsevier BV |
record_format | dspace |
spelling | mit-1721.1/1344162024-01-02T16:09:34Z Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity Sheppard, Hadley E Dall’Agnese, Alessandra Park, Woojun D Shamim, M Hamza Dubrulle, Julien Johnson, Hannah L Stossi, Fabio Cogswell, Patricia Sommer, Josh Levy, Joan Sharifnia, Tanaz Wawer, Mathias J Nabet, Behnam Gray, Nathanael S Clemons, Paul A Schreiber, Stuart L Workman, Paul Young, Richard A Lin, Charles Y Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research © 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury targeting is a promising therapeutic strategy. 2021-10-27T20:04:55Z 2021-10-27T20:04:55Z 2021 2021-08-04T18:39:08Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134416 en 10.1016/j.xcrm.2020.100188 Cell Reports Medicine Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
spellingShingle | Sheppard, Hadley E Dall’Agnese, Alessandra Park, Woojun D Shamim, M Hamza Dubrulle, Julien Johnson, Hannah L Stossi, Fabio Cogswell, Patricia Sommer, Josh Levy, Joan Sharifnia, Tanaz Wawer, Mathias J Nabet, Behnam Gray, Nathanael S Clemons, Paul A Schreiber, Stuart L Workman, Paul Young, Richard A Lin, Charles Y Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity |
title | Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity |
title_full | Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity |
title_fullStr | Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity |
title_full_unstemmed | Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity |
title_short | Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity |
title_sort | targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity |
url | https://hdl.handle.net/1721.1/134416 |
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