Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

© 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury tar...

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Main Authors: Sheppard, Hadley E, Dall’Agnese, Alessandra, Park, Woojun D, Shamim, M Hamza, Dubrulle, Julien, Johnson, Hannah L, Stossi, Fabio, Cogswell, Patricia, Sommer, Josh, Levy, Joan, Sharifnia, Tanaz, Wawer, Mathias J, Nabet, Behnam, Gray, Nathanael S, Clemons, Paul A, Schreiber, Stuart L, Workman, Paul, Young, Richard A, Lin, Charles Y
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/134416
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author Sheppard, Hadley E
Dall’Agnese, Alessandra
Park, Woojun D
Shamim, M Hamza
Dubrulle, Julien
Johnson, Hannah L
Stossi, Fabio
Cogswell, Patricia
Sommer, Josh
Levy, Joan
Sharifnia, Tanaz
Wawer, Mathias J
Nabet, Behnam
Gray, Nathanael S
Clemons, Paul A
Schreiber, Stuart L
Workman, Paul
Young, Richard A
Lin, Charles Y
author2 Massachusetts Institute of Technology. Department of Biology
author_facet Massachusetts Institute of Technology. Department of Biology
Sheppard, Hadley E
Dall’Agnese, Alessandra
Park, Woojun D
Shamim, M Hamza
Dubrulle, Julien
Johnson, Hannah L
Stossi, Fabio
Cogswell, Patricia
Sommer, Josh
Levy, Joan
Sharifnia, Tanaz
Wawer, Mathias J
Nabet, Behnam
Gray, Nathanael S
Clemons, Paul A
Schreiber, Stuart L
Workman, Paul
Young, Richard A
Lin, Charles Y
author_sort Sheppard, Hadley E
collection MIT
description © 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury targeting is a promising therapeutic strategy.
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spelling mit-1721.1/1344162024-01-02T16:09:34Z Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity Sheppard, Hadley E Dall’Agnese, Alessandra Park, Woojun D Shamim, M Hamza Dubrulle, Julien Johnson, Hannah L Stossi, Fabio Cogswell, Patricia Sommer, Josh Levy, Joan Sharifnia, Tanaz Wawer, Mathias J Nabet, Behnam Gray, Nathanael S Clemons, Paul A Schreiber, Stuart L Workman, Paul Young, Richard A Lin, Charles Y Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research © 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury targeting is a promising therapeutic strategy. 2021-10-27T20:04:55Z 2021-10-27T20:04:55Z 2021 2021-08-04T18:39:08Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134416 en 10.1016/j.xcrm.2020.100188 Cell Reports Medicine Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier
spellingShingle Sheppard, Hadley E
Dall’Agnese, Alessandra
Park, Woojun D
Shamim, M Hamza
Dubrulle, Julien
Johnson, Hannah L
Stossi, Fabio
Cogswell, Patricia
Sommer, Josh
Levy, Joan
Sharifnia, Tanaz
Wawer, Mathias J
Nabet, Behnam
Gray, Nathanael S
Clemons, Paul A
Schreiber, Stuart L
Workman, Paul
Young, Richard A
Lin, Charles Y
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
title Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
title_full Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
title_fullStr Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
title_full_unstemmed Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
title_short Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
title_sort targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
url https://hdl.handle.net/1721.1/134416
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