Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

© 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury tar...

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Detalhes bibliográficos
Principais autores: Sheppard, Hadley E, Dall’Agnese, Alessandra, Park, Woojun D, Shamim, M Hamza, Dubrulle, Julien, Johnson, Hannah L, Stossi, Fabio, Cogswell, Patricia, Sommer, Josh, Levy, Joan, Sharifnia, Tanaz, Wawer, Mathias J, Nabet, Behnam, Gray, Nathanael S, Clemons, Paul A, Schreiber, Stuart L, Workman, Paul, Young, Richard A, Lin, Charles Y
Outros Autores: Massachusetts Institute of Technology. Department of Biology
Formato: Artigo
Idioma:English
Publicado em: Elsevier BV 2021
Acesso em linha:https://hdl.handle.net/1721.1/134416

Internet

https://hdl.handle.net/1721.1/134416

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