Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

© 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury tar...

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Bibliographic Details
Main Authors: Sheppard, Hadley E, Dall’Agnese, Alessandra, Park, Woojun D, Shamim, M Hamza, Dubrulle, Julien, Johnson, Hannah L, Stossi, Fabio, Cogswell, Patricia, Sommer, Josh, Levy, Joan, Sharifnia, Tanaz, Wawer, Mathias J, Nabet, Behnam, Gray, Nathanael S, Clemons, Paul A, Schreiber, Stuart L, Workman, Paul, Young, Richard A, Lin, Charles Y
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/134416

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