The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres
Injectable blood persistent particulate carriers have important therapeutic application in site-specific drug delivery or medical imaging. However, injected particles are generally eliminated by the reticulo-endothelial system within minutes after administration and accumulate in the liver and splee...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/134465 |
| _version_ | 1826195536517005312 |
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| author | Gref, R Domb, A Quellec, P Blunk, T Müller, RH Verbavatz, JM Langer, R |
| author_facet | Gref, R Domb, A Quellec, P Blunk, T Müller, RH Verbavatz, JM Langer, R |
| author_sort | Gref, R |
| collection | MIT |
| description | Injectable blood persistent particulate carriers have important therapeutic application in site-specific drug delivery or medical imaging. However, injected particles are generally eliminated by the reticulo-endothelial system within minutes after administration and accumulate in the liver and spleen. To obtain a coating that might prevent opsonization and subsequent recognition by the macrophages, sterically stabilized nanospheres were developed using amphiphilic diblock or multiblock copolymers. The nanospheres are composed of a hydrophilic polyethylene glycol coating and a biodegradable core in which various drugs were encapsulated. Hydrophobic drugs, such as lidocaine, were entrapped up to 45. wt% and the release kinetics were governed by the polymer physico-chemical characteristics. Plasma protein adsorption was drastically reduced on PEG-coated particles compared to non-coated ones. Relative protein amounts were time-dependent. The nanospheres exhibited increased blood circulation times and reduced liver accumulation, depending on the coating polyethylene glycol molecular weight and surface density. They could be freeze-dried and redispersed in aqueous solutions and possess good shelf stability. It may be possible to tailor "optimal" polymers for given therapeutic applications. © 2012. |
| first_indexed | 2024-09-23T10:14:17Z |
| format | Article |
| id | mit-1721.1/134465 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:14:17Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1344652022-03-30T14:46:45Z The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres Gref, R Domb, A Quellec, P Blunk, T Müller, RH Verbavatz, JM Langer, R Injectable blood persistent particulate carriers have important therapeutic application in site-specific drug delivery or medical imaging. However, injected particles are generally eliminated by the reticulo-endothelial system within minutes after administration and accumulate in the liver and spleen. To obtain a coating that might prevent opsonization and subsequent recognition by the macrophages, sterically stabilized nanospheres were developed using amphiphilic diblock or multiblock copolymers. The nanospheres are composed of a hydrophilic polyethylene glycol coating and a biodegradable core in which various drugs were encapsulated. Hydrophobic drugs, such as lidocaine, were entrapped up to 45. wt% and the release kinetics were governed by the polymer physico-chemical characteristics. Plasma protein adsorption was drastically reduced on PEG-coated particles compared to non-coated ones. Relative protein amounts were time-dependent. The nanospheres exhibited increased blood circulation times and reduced liver accumulation, depending on the coating polyethylene glycol molecular weight and surface density. They could be freeze-dried and redispersed in aqueous solutions and possess good shelf stability. It may be possible to tailor "optimal" polymers for given therapeutic applications. © 2012. 2021-10-27T20:05:07Z 2021-10-27T20:05:07Z 2012 2019-09-04T17:46:09Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134465 Gref, R., et al. "The Controlled Intravenous Delivery of Drugs Using Peg-Coated Sterically Stabilized Nanospheres." (2012). en 10.1016/j.addr.2012.09.008 Advanced Drug Delivery Reviews Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Gref, R Domb, A Quellec, P Blunk, T Müller, RH Verbavatz, JM Langer, R The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres |
| title | The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres |
| title_full | The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres |
| title_fullStr | The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres |
| title_full_unstemmed | The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres |
| title_short | The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres |
| title_sort | controlled intravenous delivery of drugs using peg coated sterically stabilized nanospheres |
| url | https://hdl.handle.net/1721.1/134465 |
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