Process intensification and optimization for hydroxyapatite nanoparticles production
Precipitation processes are widely used in industry for the production of particulate solids. Efficient mixing of the reagents is of major importance for the chemical and physical nature of the synthesized particles. Recently, microreactors have been studied to overcome homogeneity problems found wh...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/134470 |
| _version_ | 1826211539773816832 |
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| author | Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, António Rocha, Fernando Vicente, António Teixeira, José António |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, António Rocha, Fernando Vicente, António Teixeira, José António |
| author_sort | Castro, Filipa |
| collection | MIT |
| description | Precipitation processes are widely used in industry for the production of particulate solids. Efficient mixing of the reagents is of major importance for the chemical and physical nature of the synthesized particles. Recently, microreactors have been studied to overcome homogeneity problems found when using stirred tank batch reactors. The present work investigated an ultrasonic tubular microreactor for the continuous-flow precipitation of hydroxyapatite (HAp), both in single-phase flow (SPF) and in gas-liquid flow (GLF). HAp nanoparticles were yielded for both configurations under near-physiological conditions of pH and temperature. The as-prepared particles, especially those that were prepared under GLF, show improved characteristics compared to commercial powder or powder obtained in a stirred tank batch reactor. Primary particles are smaller, particle shape is more homogeneous, and the aggregation degree of the particles is lower. © 2013 Elsevier Ltd. |
| first_indexed | 2024-09-23T15:07:37Z |
| format | Article |
| id | mit-1721.1/134470 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:07:37Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1344702023-10-05T19:45:41Z Process intensification and optimization for hydroxyapatite nanoparticles production Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, António Rocha, Fernando Vicente, António Teixeira, José António Massachusetts Institute of Technology. Department of Chemical Engineering Precipitation processes are widely used in industry for the production of particulate solids. Efficient mixing of the reagents is of major importance for the chemical and physical nature of the synthesized particles. Recently, microreactors have been studied to overcome homogeneity problems found when using stirred tank batch reactors. The present work investigated an ultrasonic tubular microreactor for the continuous-flow precipitation of hydroxyapatite (HAp), both in single-phase flow (SPF) and in gas-liquid flow (GLF). HAp nanoparticles were yielded for both configurations under near-physiological conditions of pH and temperature. The as-prepared particles, especially those that were prepared under GLF, show improved characteristics compared to commercial powder or powder obtained in a stirred tank batch reactor. Primary particles are smaller, particle shape is more homogeneous, and the aggregation degree of the particles is lower. © 2013 Elsevier Ltd. 2021-10-27T20:05:09Z 2021-10-27T20:05:09Z 2013 2019-08-22T11:47:02Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134470 Castro, F., et al. "Process Intensification and Optimization for Hydroxyapatite Nanoparticles Production." Chemical Engineering Science (2013). en 10.1016/j.ces.2013.01.002 Chemical Engineering Science Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Other repository |
| spellingShingle | Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, António Rocha, Fernando Vicente, António Teixeira, José António Process intensification and optimization for hydroxyapatite nanoparticles production |
| title | Process intensification and optimization for hydroxyapatite nanoparticles production |
| title_full | Process intensification and optimization for hydroxyapatite nanoparticles production |
| title_fullStr | Process intensification and optimization for hydroxyapatite nanoparticles production |
| title_full_unstemmed | Process intensification and optimization for hydroxyapatite nanoparticles production |
| title_short | Process intensification and optimization for hydroxyapatite nanoparticles production |
| title_sort | process intensification and optimization for hydroxyapatite nanoparticles production |
| url | https://hdl.handle.net/1721.1/134470 |
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