Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
© 2014 Macmillan Publishers Limited. All rights reserved. The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, poses substantial challenges owing to their large size and susceptibility to degradation. In this Review we highlight recent adva...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/134499 |
| _version_ | 1826196998045302784 |
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| author | Mitragotri, Samir Burke, Paul A Langer, Robert |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Mitragotri, Samir Burke, Paul A Langer, Robert |
| author_sort | Mitragotri, Samir |
| collection | MIT |
| description | © 2014 Macmillan Publishers Limited. All rights reserved. The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, poses substantial challenges owing to their large size and susceptibility to degradation. In this Review we highlight recent advances in formulation and delivery strategies - such as the use of microsphere-based controlled-release technologies, protein modification methods that make use of polyethylene glycol and other polymers, and genetic manipulation of biopharmaceutical drugs - and discuss their advantages and limitations. We also highlight current and emerging delivery routes that provide an alternative to injection, including transdermal, oral and pulmonary delivery routes. In addition, the potential of targeted and intracellular protein delivery is discussed. |
| first_indexed | 2024-09-23T10:41:09Z |
| format | Article |
| id | mit-1721.1/134499 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:41:09Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1344992023-12-14T15:29:55Z Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies Mitragotri, Samir Burke, Paul A Langer, Robert Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT © 2014 Macmillan Publishers Limited. All rights reserved. The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, poses substantial challenges owing to their large size and susceptibility to degradation. In this Review we highlight recent advances in formulation and delivery strategies - such as the use of microsphere-based controlled-release technologies, protein modification methods that make use of polyethylene glycol and other polymers, and genetic manipulation of biopharmaceutical drugs - and discuss their advantages and limitations. We also highlight current and emerging delivery routes that provide an alternative to injection, including transdermal, oral and pulmonary delivery routes. In addition, the potential of targeted and intracellular protein delivery is discussed. 2021-10-27T20:05:18Z 2021-10-27T20:05:18Z 2014 2019-09-05T16:44:17Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134499 Mitragotri, S., P. A. Burke, and R. Langer. "Overcoming the Challenges in Administering Biopharmaceuticals: Formulation and Delivery Strategies." Nat Rev Drug Discov 13 9 (2014): 655-72. en 10.1038/NRD4363 Nature Reviews Drug Discovery Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Science and Business Media LLC PMC |
| spellingShingle | Mitragotri, Samir Burke, Paul A Langer, Robert Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies |
| title | Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies |
| title_full | Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies |
| title_fullStr | Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies |
| title_full_unstemmed | Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies |
| title_short | Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies |
| title_sort | overcoming the challenges in administering biopharmaceuticals formulation and delivery strategies |
| url | https://hdl.handle.net/1721.1/134499 |
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