Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

© 2014 Macmillan Publishers Limited. All rights reserved. The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, poses substantial challenges owing to their large size and susceptibility to degradation. In this Review we highlight recent adva...

Full description

Bibliographic Details
Main Authors:	Mitragotri, Samir, Burke, Paul A, Langer, Robert
Other Authors:	Massachusetts Institute of Technology. Department of Chemical Engineering
Format:	Article
Language:	English
Published:	Springer Science and Business Media LLC 2021
Online Access:	https://hdl.handle.net/1721.1/134499

Similar Items

Ultrasound-mediated transdermal drug delivery : mechanisms and applications
by: Mitragotri, Samir
Published: (2005)

Supramolecular PEGylation of biopharmaceuticals
by: Vinciguerra, Brittany, et al.
Published: (2017)

Engineering Medical Devices to Improve Oral Delivery of Biopharmaceuticals
by: Sharma, Shonit Nair
Published: (2024)

Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems
by: Subramanian, Deepak A., et al.
Published: (2022)

Employing Drug Delivery Strategies to Overcome Challenges Using TLR7/8 Agonists for Cancer Immunotherapy
by: Varshney, Dhruv, et al.
Published: (2021)

Employing Drug Delivery Strategies to Overcome Challenges Using TLR7/8 Agonists for Cancer Immunotherapy
by: Varshney, Dhruv, et al.
Published: (2022)

Advanced strategies to enhance the performances of crystallization and precipitation of biopharmaceuticals
by: Pu, Siyu
Published: (2023)

Nano-gene-delivery: overcoming one of the major challenges in gene therapy
by: Trigueros, S
Published: (2018)

Globalization of biopharmaceutical manufacturing
by: Pande, Rachna
Published: (2012)

Engineering of Escherichia coli strains for plasmid biopharmaceutical production: Scale-up challenges
by: Monteiro, Gabriel A., et al.
Published: (2016)

Formulations for trans-tympanic antibiotic delivery
by: Khoo, Xiaojuan, et al.
Published: (2020)

Variation reduction in biopharmaceutical manufacturing
by: Steltenpohl, Kurt Maus
Published: (2013)

Evaluation of marking technology for risk management in the biopharmaceutical supply chain
by: Hardy, Robert (Robert Andrew)
Published: (2012)

Investigating investment in biopharmaceutical R&D
by: Carter, Percy H., et al.
Published: (2017)

On-demand manufacturing of clinical-quality biopharmaceuticals
by: Crowell, Laura E, et al.
Published: (2021)

Potentials and challenges of Levodopa particle formulation for treatment of Parkinson's disease through intranasal and pulmonary delivery
by: Paul, Mahasweta, et al.
Published: (2022)

Biopharmaceuticals protection, cure and the real winner
by: Mohd Lila, Mohd Azmi
Published: (2011)

Understanding risk in a biopharmaceutical portfolio
by: Wagner, Alice Elizabeth, 1980-
Published: (2012)

Process Analytical Technology in biopharmaceutical manufacturing
by: Cosby, Samuel T. (Samuel Thomas)
Published: (2013)

Ionic liquid‐mediated transdermal delivery of thrombosis‐detecting nanosensors
by: Bekdemir, Ahmet, et al.
Published: (2022)

Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide
by: Appelbe, Oliver K., et al.
Published: (2019)

Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer
by: Urbanska, Aleksandra M., et al.
Published: (2015)

Overcoming the challenges of membrane protein crystallography.
by: Carpenter, E, et al.
Published: (2008)

Rapid optimization of processes for the integrated purification of biopharmaceuticals
by: Crowell, Laura E, et al.
Published: (2021)

Development of a risk management system for consumables used in biopharmaceutical manufacturing
by: Linders, David (David Robert)
Published: (2013)

Vertical integration and strategic sourcing in the biopharmaceutical industry
by: Haupt, Lynne Felice
Published: (2006)

Lean transformation methodology and implementation in biopharmaceutical operations
by: Villa, Adam Daniel
Published: (2009)

Magnetically enhanced centrifugation for continuous biopharmaceutical processing
by: Chen, Fei, Ph. D. Massachusetts Institute of Technology
Published: (2010)

Process management applications in biopharmaceutical drug production
by: Smith, Stephen E
Published: (2011)

Evaluating future biopharmaceutical inspection needs, infrastructure capability gaps, and technology development strategies
by: Hollander, Marnix E. (Marnix English)
Published: (2012)

Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology
by: Afonin, Kirill A, et al.
Published: (2021)

Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology
by: Afonin, Kirill A, et al.
Published: (2021)

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy
by: Razavi, M., et al.
Published: (2016)

The Life Between Big Data Log Events: Learners’ Strategies to Overcome Challenges in MOOCs
by: Veletsianos, George, et al.
Published: (2021)

Including children with autism: overcoming the challenge of integration.
by: Hussin, S., et al.
Published: (2008)

Challenges for operationalizing autonomous Enterprise: what to overcome?
by: Merdekawati, A., et al.
Published: (2023)

Ultrasound-enhanced transdermal delivery: recent advances and future challenges
by: Blankschtein, Daniel, et al.
Published: (2016)

Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy
by: Ardenkjaer-Larsen, Jan-Henrik, et al.
Published: (2017)

Congenital Vascular Ring: Overcoming Perioperative Challenges
by: Chong, Soon Eu, et al.
Published: (2016)

Can ASEAN overcome challenges to digital development?
by: Toh, Anthony Han Yang
Published: (2023)