Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis
A novel, compact-sized (19 cm × 16 cm) and portable (500 g) magnetic resonance relaxometry system is designed and developed. We overcame several key engineering barriers so that magnetic resonance technology can be potentially used for disease diagnosis-monitoring in point-of-care settings, directly...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing
2021
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| Online Access: | https://hdl.handle.net/1721.1/134501 |
| _version_ | 1826203216168091648 |
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| author | Peng, Weng Kung Chen, Lan Han, Jongyoon |
| author2 | Singapore-MIT Alliance in Research and Technology (SMART) |
| author_facet | Singapore-MIT Alliance in Research and Technology (SMART) Peng, Weng Kung Chen, Lan Han, Jongyoon |
| author_sort | Peng, Weng Kung |
| collection | MIT |
| description | A novel, compact-sized (19 cm × 16 cm) and portable (500 g) magnetic resonance relaxometry system is designed and developed. We overcame several key engineering barriers so that magnetic resonance technology can be potentially used for disease diagnosis-monitoring in point-of-care settings, directly on biological cells and tissues. The whole system consists of a coin-sized permanent magnet (0.76 T), miniaturized radio-frequency microcoil probe, compact lumped-circuit duplexer, and single board 1-W power amplifier, in which a field programmable gate array -based spectrometer is used for pulse excitation, signal acquisition, and data processing. We show that by measuring the proton transverse relaxation rates from a large pool of natural abundance proton-nuclei presence in less than 1 μL of red blood cells, one can indirectly deduce the relative magnetic susceptibility of the bulk cells within a few minutes of signal acquisition time. Such rapid and sensitive blood screening system can be used to monitor the fluctuation of the bulk magnetic susceptibility of the biological cells (e.g., human blood cells), where unusual state of the bulk magnetic susceptibility is related to a number of diseases. © 2012 American Institute of Physics. |
| first_indexed | 2024-09-23T12:33:10Z |
| format | Article |
| id | mit-1721.1/134501 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:33:10Z |
| publishDate | 2021 |
| publisher | AIP Publishing |
| record_format | dspace |
| spelling | mit-1721.1/1345012023-02-22T17:25:36Z Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis Peng, Weng Kung Chen, Lan Han, Jongyoon Singapore-MIT Alliance in Research and Technology (SMART) Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Biological Engineering A novel, compact-sized (19 cm × 16 cm) and portable (500 g) magnetic resonance relaxometry system is designed and developed. We overcame several key engineering barriers so that magnetic resonance technology can be potentially used for disease diagnosis-monitoring in point-of-care settings, directly on biological cells and tissues. The whole system consists of a coin-sized permanent magnet (0.76 T), miniaturized radio-frequency microcoil probe, compact lumped-circuit duplexer, and single board 1-W power amplifier, in which a field programmable gate array -based spectrometer is used for pulse excitation, signal acquisition, and data processing. We show that by measuring the proton transverse relaxation rates from a large pool of natural abundance proton-nuclei presence in less than 1 μL of red blood cells, one can indirectly deduce the relative magnetic susceptibility of the bulk cells within a few minutes of signal acquisition time. Such rapid and sensitive blood screening system can be used to monitor the fluctuation of the bulk magnetic susceptibility of the biological cells (e.g., human blood cells), where unusual state of the bulk magnetic susceptibility is related to a number of diseases. © 2012 American Institute of Physics. 2021-10-27T20:05:18Z 2021-10-27T20:05:18Z 2012 2019-06-05T14:23:13Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134501 en 10.1063/1.4754296 Review of Scientific Instruments Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf AIP Publishing Other repository |
| spellingShingle | Peng, Weng Kung Chen, Lan Han, Jongyoon Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis |
| title | Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis |
| title_full | Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis |
| title_fullStr | Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis |
| title_full_unstemmed | Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis |
| title_short | Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis |
| title_sort | development of miniaturized portable magnetic resonance relaxometry system for point of care medical diagnosis |
| url | https://hdl.handle.net/1721.1/134501 |
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