Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation
The use of tissue adhesives for internal clinical applications is limited due to a lack of materials that balance strong adhesion with biocompatibility. The use of substrate topography is explored to reduce the volume of a highly reactive and toxic glue without compromising adhesive strength. Micro-...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| 其他作者: | |
| 格式: | 文件 |
| 语言: | English |
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Wiley
2021
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| 在线阅读: | https://hdl.handle.net/1721.1/134514 |
| _version_ | 1826212312118198272 |
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| author | Pereira, Maria JN Sundback, Cathryn A Lang, Nora Cho, Woo Kyung Pomerantseva, Irina Ouyang, Ben Tao, Sarah L McHugh, Kevin Mwizerwa, Olive Vemula, Praveen K Mochel, Mark C Carter, David J Borenstein, Jeffrey T Langer, Robert Ferreira, Lino S Karp, Jeffrey M Masiakos, Peter T |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Pereira, Maria JN Sundback, Cathryn A Lang, Nora Cho, Woo Kyung Pomerantseva, Irina Ouyang, Ben Tao, Sarah L McHugh, Kevin Mwizerwa, Olive Vemula, Praveen K Mochel, Mark C Carter, David J Borenstein, Jeffrey T Langer, Robert Ferreira, Lino S Karp, Jeffrey M Masiakos, Peter T |
| author_sort | Pereira, Maria JN |
| collection | MIT |
| description | The use of tissue adhesives for internal clinical applications is limited due to a lack of materials that balance strong adhesion with biocompatibility. The use of substrate topography is explored to reduce the volume of a highly reactive and toxic glue without compromising adhesive strength. Micro-textured patches coated with a thin layer of cyanoacrylate glue achieve similar adhesion levels to patches employing large amounts of adhesive, and is superior to the level of adhesion achieved when a thin coating is applied to a non-textured patch. In vivo studies demonstrate reduced tissue inflammation and necrosis for patterned patches with a thinly coated layer of reactive glue, thus overcoming a significant challenge with existing tissue adhesives such as cyanoacrylate. Closure of surgical stomach and colon defects in a rat model is achieved without abdominal adhesions. Harnessing the synergy between surface topography and reactive chemistry enables controlled tissue adhesion with an improved biocompatibility profile without requiring changes in the chemical composition of reactive tissue glues. The use of substrate topography is explored to reduce the amount of a highly reactive and toxic tissue glue without compromising adhesive strength. Micro-textured patches coated with a thin layer of cyanoacrylate glue achieve similar adhesion levels as flat patches employing a thick layer of glue. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| first_indexed | 2024-09-23T15:19:44Z |
| format | Article |
| id | mit-1721.1/134514 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:19:44Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1345142023-10-05T19:47:37Z Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation Pereira, Maria JN Sundback, Cathryn A Lang, Nora Cho, Woo Kyung Pomerantseva, Irina Ouyang, Ben Tao, Sarah L McHugh, Kevin Mwizerwa, Olive Vemula, Praveen K Mochel, Mark C Carter, David J Borenstein, Jeffrey T Langer, Robert Ferreira, Lino S Karp, Jeffrey M Masiakos, Peter T Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT The use of tissue adhesives for internal clinical applications is limited due to a lack of materials that balance strong adhesion with biocompatibility. The use of substrate topography is explored to reduce the volume of a highly reactive and toxic glue without compromising adhesive strength. Micro-textured patches coated with a thin layer of cyanoacrylate glue achieve similar adhesion levels to patches employing large amounts of adhesive, and is superior to the level of adhesion achieved when a thin coating is applied to a non-textured patch. In vivo studies demonstrate reduced tissue inflammation and necrosis for patterned patches with a thinly coated layer of reactive glue, thus overcoming a significant challenge with existing tissue adhesives such as cyanoacrylate. Closure of surgical stomach and colon defects in a rat model is achieved without abdominal adhesions. Harnessing the synergy between surface topography and reactive chemistry enables controlled tissue adhesion with an improved biocompatibility profile without requiring changes in the chemical composition of reactive tissue glues. The use of substrate topography is explored to reduce the amount of a highly reactive and toxic tissue glue without compromising adhesive strength. Micro-textured patches coated with a thin layer of cyanoacrylate glue achieve similar adhesion levels as flat patches employing a thick layer of glue. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 2021-10-27T20:05:21Z 2021-10-27T20:05:21Z 2014 2019-09-05T16:07:40Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134514 Pereira, M. J., et al. "Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation." Adv Healthc Mater (2013). en 10.1002/ADHM.201300264 Advanced Healthcare Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC |
| spellingShingle | Pereira, Maria JN Sundback, Cathryn A Lang, Nora Cho, Woo Kyung Pomerantseva, Irina Ouyang, Ben Tao, Sarah L McHugh, Kevin Mwizerwa, Olive Vemula, Praveen K Mochel, Mark C Carter, David J Borenstein, Jeffrey T Langer, Robert Ferreira, Lino S Karp, Jeffrey M Masiakos, Peter T Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation |
| title | Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation |
| title_full | Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation |
| title_fullStr | Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation |
| title_full_unstemmed | Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation |
| title_short | Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation |
| title_sort | combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation |
| url | https://hdl.handle.net/1721.1/134514 |
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