A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers

3D microfluidic networks are fabricated in a gelatin hydrogel using sacrificial melt-spun microfibers made from a material with pH-dependent solubility. The fibers, after being embedded within the gel, can be removed by changing the gel pH to induce dissolution. This process is performed in an entir...

Full description

Bibliographic Details
Main Authors: Bellan, Leon M, Pearsall, Matthew, Cropek, Donald M, Langer, Robert
Format: Article
Language:English
Published: Wiley 2021
Online Access:https://hdl.handle.net/1721.1/134515
_version_ 1826206728366063616
author Bellan, Leon M
Pearsall, Matthew
Cropek, Donald M
Langer, Robert
author_facet Bellan, Leon M
Pearsall, Matthew
Cropek, Donald M
Langer, Robert
author_sort Bellan, Leon M
collection MIT
description 3D microfluidic networks are fabricated in a gelatin hydrogel using sacrificial melt-spun microfibers made from a material with pH-dependent solubility. The fibers, after being embedded within the gel, can be removed by changing the gel pH to induce dissolution. This process is performed in an entirely aqueous environment, avoiding extreme temperatures, low pressures, and toxic organic solvents. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
first_indexed 2024-09-23T13:37:37Z
format Article
id mit-1721.1/134515
institution Massachusetts Institute of Technology
language English
last_indexed 2024-09-23T13:37:37Z
publishDate 2021
publisher Wiley
record_format dspace
spelling mit-1721.1/1345152022-03-29T20:43:01Z A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers Bellan, Leon M Pearsall, Matthew Cropek, Donald M Langer, Robert 3D microfluidic networks are fabricated in a gelatin hydrogel using sacrificial melt-spun microfibers made from a material with pH-dependent solubility. The fibers, after being embedded within the gel, can be removed by changing the gel pH to induce dissolution. This process is performed in an entirely aqueous environment, avoiding extreme temperatures, low pressures, and toxic organic solvents. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 2021-10-27T20:05:22Z 2021-10-27T20:05:22Z 2012 2019-09-04T17:25:10Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134515 Bellan, L. M., et al. "A 3d Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers." Adv Mater (2012). en 10.1002/adma.201200810 Advanced Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC
spellingShingle Bellan, Leon M
Pearsall, Matthew
Cropek, Donald M
Langer, Robert
A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers
title A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers
title_full A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers
title_fullStr A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers
title_full_unstemmed A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers
title_short A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers
title_sort 3d interconnected microchannel network formed in gelatin by sacrificial shellac microfibers
url https://hdl.handle.net/1721.1/134515
work_keys_str_mv AT bellanleonm a3dinterconnectedmicrochannelnetworkformedingelatinbysacrificialshellacmicrofibers
AT pearsallmatthew a3dinterconnectedmicrochannelnetworkformedingelatinbysacrificialshellacmicrofibers
AT cropekdonaldm a3dinterconnectedmicrochannelnetworkformedingelatinbysacrificialshellacmicrofibers
AT langerrobert a3dinterconnectedmicrochannelnetworkformedingelatinbysacrificialshellacmicrofibers
AT bellanleonm 3dinterconnectedmicrochannelnetworkformedingelatinbysacrificialshellacmicrofibers
AT pearsallmatthew 3dinterconnectedmicrochannelnetworkformedingelatinbysacrificialshellacmicrofibers
AT cropekdonaldm 3dinterconnectedmicrochannelnetworkformedingelatinbysacrificialshellacmicrofibers
AT langerrobert 3dinterconnectedmicrochannelnetworkformedingelatinbysacrificialshellacmicrofibers