Controlling Spatial Organization of Multiple Cell Types in Defined 3D Geometries

A simple method to control spatial organizations of multiple cell types in predefined geometries by using poly(N-isopropylacrylamide)-based dynamic microwells is described. Dynamic microwells are used to pattern two different cell types in a spatially controlled manner by exploiting their shape chan...

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Bibliographic Details
Main Authors: Tekin, Halil, Sanchez, Jefferson G, Landeros, Christian, Dubbin, Karen, Langer, Robert, Khademhosseini, Ali
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Language:English
Published: Wiley 2021
Online Access:https://hdl.handle.net/1721.1/134516
Description
Summary:A simple method to control spatial organizations of multiple cell types in predefined geometries by using poly(N-isopropylacrylamide)-based dynamic microwells is described. Dynamic microwells are used to pattern two different cell types in a spatially controlled manner by exploiting their shape changing properties at two different temperatures. Both spatial organization of two different cell types and control of pattern geometry are achieved with circular and square dynamic microwells. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.