Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold
Injectable hydrogels may potentially be used for augmentation/regeneration of the lamina propria of vocal fold tissue. In this study, hyaluronic acid (HA) and dextran were chemically modified and subsequently crosslinked via formation of hydrazone bonds in phosphate buffer. Swelling ratios, degradat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021
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| Online Access: | https://hdl.handle.net/1721.1/134536 |
| _version_ | 1826188597173157888 |
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| author | Luo, Ying Kobler, James B Heaton, James T Jia, Xinqiao Zeitels, Steven M Langer, Robert |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Luo, Ying Kobler, James B Heaton, James T Jia, Xinqiao Zeitels, Steven M Langer, Robert |
| author_sort | Luo, Ying |
| collection | MIT |
| description | Injectable hydrogels may potentially be used for augmentation/regeneration of the lamina propria of vocal fold tissue. In this study, hyaluronic acid (HA) and dextran were chemically modified and subsequently crosslinked via formation of hydrazone bonds in phosphate buffer. Swelling ratios, degradation, and compressive moduli of the resulting hydrogels were investigated. It was found that the properties of HA-dextran hydrogels were variable and the trend of variation could be correlated with the hydrogel composition. The biocompatibility of three injectable HA-dextran hydrogels with different crosslinking density was assessed in the vocal fold region using a ferret model. It was found that HA-dextran hydrogels implanted for three weeks stimulated mild foreignbody reactions. Distinct tissue-material interactions were also observed for hydrogels made from different formulations: the hydrogel with the lowest crosslinking density was completely degraded in vivo; while material residues were visible for other types of hydrogel injections, with or without cell penetration into the implantation depending on the hydrogel composition. The in vivo results suggest that the HA-dextran hydrogel matrices can be further developed for applications of vocal fold tissue restoration. © 2010 Wiley Periodicals, Inc. |
| first_indexed | 2024-09-23T08:02:09Z |
| format | Article |
| id | mit-1721.1/134536 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:02:09Z |
| publishDate | 2021 |
| publisher | Wiley |
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| spelling | mit-1721.1/1345362023-02-22T21:35:32Z Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold Luo, Ying Kobler, James B Heaton, James T Jia, Xinqiao Zeitels, Steven M Langer, Robert Massachusetts Institute of Technology. Department of Chemical Engineering Injectable hydrogels may potentially be used for augmentation/regeneration of the lamina propria of vocal fold tissue. In this study, hyaluronic acid (HA) and dextran were chemically modified and subsequently crosslinked via formation of hydrazone bonds in phosphate buffer. Swelling ratios, degradation, and compressive moduli of the resulting hydrogels were investigated. It was found that the properties of HA-dextran hydrogels were variable and the trend of variation could be correlated with the hydrogel composition. The biocompatibility of three injectable HA-dextran hydrogels with different crosslinking density was assessed in the vocal fold region using a ferret model. It was found that HA-dextran hydrogels implanted for three weeks stimulated mild foreignbody reactions. Distinct tissue-material interactions were also observed for hydrogels made from different formulations: the hydrogel with the lowest crosslinking density was completely degraded in vivo; while material residues were visible for other types of hydrogel injections, with or without cell penetration into the implantation depending on the hydrogel composition. The in vivo results suggest that the HA-dextran hydrogel matrices can be further developed for applications of vocal fold tissue restoration. © 2010 Wiley Periodicals, Inc. 2021-10-27T20:05:27Z 2021-10-27T20:05:27Z 2010 2019-08-22T19:05:31Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134536 Luo, Y., et al. "Injectable Hyaluronic Acid-Dextran Hydrogels and Effects of Implantation in Ferret Vocal Fold." Journal of Biomedical Materials Research Part B-Applied Biomaterials 93B 2 (2010): 386-93. en 10.1002/jbm.b.31593 Journal of Biomedical Materials Research - Part B Applied Biomaterials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC |
| spellingShingle | Luo, Ying Kobler, James B Heaton, James T Jia, Xinqiao Zeitels, Steven M Langer, Robert Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold |
| title | Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold |
| title_full | Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold |
| title_fullStr | Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold |
| title_full_unstemmed | Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold |
| title_short | Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold |
| title_sort | injectable hyaluronic acid dextran hydrogels and effects of implantation in ferret vocal fold |
| url | https://hdl.handle.net/1721.1/134536 |
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