Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging
© 2017 American Chemical Society. Active targeting of nanoparticles through surface functionalization is a common strategy to enhance tumor delivery specificity. However, active targeting strategies tend to work against long polyethylene glycol's shielding effectiveness and associated favorable...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society (ACS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/134578 |
| _version_ | 1826192162835922944 |
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| author | Fay, Francois Hansen, Line Hectors, Stefanie JCG Sanchez-Gaytan, Brenda L Zhao, Yiming Tang, Jun Munitz, Jazz Alaarg, Amr Braza, Mounia S Gianella, Anita Aaronson, Stuart A Reiner, Thomas Kjems, Jørgen Langer, Robert Hoeben, Freek JM Janssen, Henk M Calcagno, Claudia Strijkers, Gustav J Fayad, Zahi A Pérez-Medina, Carlos Mulder, Willem JM |
| author_facet | Fay, Francois Hansen, Line Hectors, Stefanie JCG Sanchez-Gaytan, Brenda L Zhao, Yiming Tang, Jun Munitz, Jazz Alaarg, Amr Braza, Mounia S Gianella, Anita Aaronson, Stuart A Reiner, Thomas Kjems, Jørgen Langer, Robert Hoeben, Freek JM Janssen, Henk M Calcagno, Claudia Strijkers, Gustav J Fayad, Zahi A Pérez-Medina, Carlos Mulder, Willem JM |
| author_sort | Fay, Francois |
| collection | MIT |
| description | © 2017 American Chemical Society. Active targeting of nanoparticles through surface functionalization is a common strategy to enhance tumor delivery specificity. However, active targeting strategies tend to work against long polyethylene glycol's shielding effectiveness and associated favorable pharmacokinetics. To overcome these limitations, we developed a matrix metalloproteinase-2 sensitive surface-converting polyethylene glycol coating. This coating prevents nanoparticle-cell interaction in the bloodstream, but, once exposed to matrix metalloproteinase-2, i.e., when the nanoparticles accumulate within the tumor interstitium, the converting polyethylene glycol coating is cleaved, and targeting ligands become available for binding to tumor cells. In this study, we applied a comprehensive multimodal imaging strategy involving optical, nuclear, and magnetic resonance imaging methods to evaluate this coating approach in a breast tumor mouse model. The data obtained revealed that this surface-converting coating enhances the nanoparticle's blood half-life and tumor accumulation and ultimately results in improved tumor-cell targeting. Our results show that this enzyme-specific surface-converting coating ensures a high cell-targeting specificity without compromising favorable nanoparticle pharmacokinetics. |
| first_indexed | 2024-09-23T09:07:11Z |
| format | Article |
| id | mit-1721.1/134578 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:07:11Z |
| publishDate | 2021 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1345782022-03-30T14:32:48Z Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging Fay, Francois Hansen, Line Hectors, Stefanie JCG Sanchez-Gaytan, Brenda L Zhao, Yiming Tang, Jun Munitz, Jazz Alaarg, Amr Braza, Mounia S Gianella, Anita Aaronson, Stuart A Reiner, Thomas Kjems, Jørgen Langer, Robert Hoeben, Freek JM Janssen, Henk M Calcagno, Claudia Strijkers, Gustav J Fayad, Zahi A Pérez-Medina, Carlos Mulder, Willem JM © 2017 American Chemical Society. Active targeting of nanoparticles through surface functionalization is a common strategy to enhance tumor delivery specificity. However, active targeting strategies tend to work against long polyethylene glycol's shielding effectiveness and associated favorable pharmacokinetics. To overcome these limitations, we developed a matrix metalloproteinase-2 sensitive surface-converting polyethylene glycol coating. This coating prevents nanoparticle-cell interaction in the bloodstream, but, once exposed to matrix metalloproteinase-2, i.e., when the nanoparticles accumulate within the tumor interstitium, the converting polyethylene glycol coating is cleaved, and targeting ligands become available for binding to tumor cells. In this study, we applied a comprehensive multimodal imaging strategy involving optical, nuclear, and magnetic resonance imaging methods to evaluate this coating approach in a breast tumor mouse model. The data obtained revealed that this surface-converting coating enhances the nanoparticle's blood half-life and tumor accumulation and ultimately results in improved tumor-cell targeting. Our results show that this enzyme-specific surface-converting coating ensures a high cell-targeting specificity without compromising favorable nanoparticle pharmacokinetics. 2021-10-27T20:05:38Z 2021-10-27T20:05:38Z 2017 2019-09-06T18:52:17Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134578 en 10.1021/ACS.BIOCONJCHEM.7B00086 Bioconjugate Chemistry Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Fay, Francois Hansen, Line Hectors, Stefanie JCG Sanchez-Gaytan, Brenda L Zhao, Yiming Tang, Jun Munitz, Jazz Alaarg, Amr Braza, Mounia S Gianella, Anita Aaronson, Stuart A Reiner, Thomas Kjems, Jørgen Langer, Robert Hoeben, Freek JM Janssen, Henk M Calcagno, Claudia Strijkers, Gustav J Fayad, Zahi A Pérez-Medina, Carlos Mulder, Willem JM Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging |
| title | Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging |
| title_full | Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging |
| title_fullStr | Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging |
| title_full_unstemmed | Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging |
| title_short | Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging |
| title_sort | investigating the cellular specificity in tumors of a surface converting nanoparticle by multimodal imaging |
| url | https://hdl.handle.net/1721.1/134578 |
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