A comparative genomics multitool for scientific discovery and conservation
© 2020, The Author(s). The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable...
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| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2022
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| Online Access: | https://hdl.handle.net/1721.1/134633.2 |
| _version_ | 1811072637331308544 |
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| author | Genereux, DP Serres, A Armstrong, J Johnson, J Marinescu, VD Muren, E Juan, D Bejerano, G Casewell, NR Chemnick, LG Damas, J Di Palma, F Diekhans, M Fiddes, IT Garber, M Gladyshev, NV Goodman, L Haerty, W Houck, ML Hubley, R Kivioja, T Koepfli, KP Kuderna, LFK Lander, Eric Steven Meadows, JRS Murphy, WJ Nash, W Noh, HJ Nweeia, M Pfenning, AR Pollard, KS Ray, DA Shapiro, B Smit, AFA Springer, MS Steiner, CC Swofford, R Taipale, J Teeling, EC Turner-Maier, J Alfoldi, J Birren, B Ryder, OA Lewin, HA Paten, B Marques-Bonet, T Lindblad-Toh, K Karlsson, EK |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Genereux, DP Serres, A Armstrong, J Johnson, J Marinescu, VD Muren, E Juan, D Bejerano, G Casewell, NR Chemnick, LG Damas, J Di Palma, F Diekhans, M Fiddes, IT Garber, M Gladyshev, NV Goodman, L Haerty, W Houck, ML Hubley, R Kivioja, T Koepfli, KP Kuderna, LFK Lander, Eric Steven Meadows, JRS Murphy, WJ Nash, W Noh, HJ Nweeia, M Pfenning, AR Pollard, KS Ray, DA Shapiro, B Smit, AFA Springer, MS Steiner, CC Swofford, R Taipale, J Teeling, EC Turner-Maier, J Alfoldi, J Birren, B Ryder, OA Lewin, HA Paten, B Marques-Bonet, T Lindblad-Toh, K Karlsson, EK |
| author_sort | Genereux, DP |
| collection | MIT |
| description | © 2020, The Author(s). The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity. |
| first_indexed | 2024-09-23T09:09:11Z |
| format | Article |
| id | mit-1721.1/134633.2 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:09:11Z |
| publishDate | 2022 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/134633.22022-04-14T20:12:21Z A comparative genomics multitool for scientific discovery and conservation Genereux, DP Serres, A Armstrong, J Johnson, J Marinescu, VD Muren, E Juan, D Bejerano, G Casewell, NR Chemnick, LG Damas, J Di Palma, F Diekhans, M Fiddes, IT Garber, M Gladyshev, NV Goodman, L Haerty, W Houck, ML Hubley, R Kivioja, T Koepfli, KP Kuderna, LFK Lander, Eric Steven Meadows, JRS Murphy, WJ Nash, W Noh, HJ Nweeia, M Pfenning, AR Pollard, KS Ray, DA Shapiro, B Smit, AFA Springer, MS Steiner, CC Swofford, R Taipale, J Teeling, EC Turner-Maier, J Alfoldi, J Birren, B Ryder, OA Lewin, HA Paten, B Marques-Bonet, T Lindblad-Toh, K Karlsson, EK Massachusetts Institute of Technology. Department of Biology © 2020, The Author(s). The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity. 2022-04-14T20:12:20Z 2021-10-27T20:05:54Z 2022-04-14T20:12:20Z 2020-11-12 2021-07-20T17:44:07Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134633.2 en 10.1038/s41586-020-2876-6 Nature Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/octet-stream Springer Science and Business Media LLC Nature |
| spellingShingle | Genereux, DP Serres, A Armstrong, J Johnson, J Marinescu, VD Muren, E Juan, D Bejerano, G Casewell, NR Chemnick, LG Damas, J Di Palma, F Diekhans, M Fiddes, IT Garber, M Gladyshev, NV Goodman, L Haerty, W Houck, ML Hubley, R Kivioja, T Koepfli, KP Kuderna, LFK Lander, Eric Steven Meadows, JRS Murphy, WJ Nash, W Noh, HJ Nweeia, M Pfenning, AR Pollard, KS Ray, DA Shapiro, B Smit, AFA Springer, MS Steiner, CC Swofford, R Taipale, J Teeling, EC Turner-Maier, J Alfoldi, J Birren, B Ryder, OA Lewin, HA Paten, B Marques-Bonet, T Lindblad-Toh, K Karlsson, EK A comparative genomics multitool for scientific discovery and conservation |
| title | A comparative genomics multitool for scientific discovery and conservation |
| title_full | A comparative genomics multitool for scientific discovery and conservation |
| title_fullStr | A comparative genomics multitool for scientific discovery and conservation |
| title_full_unstemmed | A comparative genomics multitool for scientific discovery and conservation |
| title_short | A comparative genomics multitool for scientific discovery and conservation |
| title_sort | comparative genomics multitool for scientific discovery and conservation |
| url | https://hdl.handle.net/1721.1/134633.2 |
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