Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer
© 2020 American Association for Cancer Research. Purpose: Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test for tracking hundreds of patient-specific mutations to detect MRD with a 1,000-fold lower e...
Main Authors: | Parsons, Heather A., Rhoades, Justin, Reed, Sarah C., Gydush, Gregory, Ram, Priyanka, Exman, Pedro, Xiong, Kan, Lo, Christopher C., Li, Tianyu, Fleharty, Mark, Kirkner, Gregory J., Rotem, Denisse, Cohen, Ofir, Yu, Fangyan, Fitarelli-Kiehl, Mariana, Leong, Ka Wai, Hughes, Melissa E., Rosenberg, Shoshana M., Collins, Laura C., Miller, Kathy D., Blumenstiel, Brendan, Trippa, Lorenzo, Cibulskis, Carrie, Neuberg, Donna S., DeFelice, Matthew, Freeman, Samuel S., Lennon, Niall J., Wagle, Nikhil, Ha, Gavin, Stover, Daniel G., Choudhury, Atish D., Getz, Gad, Winer, Eric P., Meyerson, Matthew, Lin, Nancy U., Krop, Ian, Love, J. Christopher, Makrigiorgos, G. Mike, Partridge, Ann H., Mayer, Erica L., Golub, Todd R., Adalsteinsson, Viktor A. |
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Other Authors: | Koch Institute for Integrative Cancer Research at MIT |
Format: | Article |
Language: | English |
Published: |
American Association for Cancer Research (AACR)
2022
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Online Access: | https://hdl.handle.net/1721.1/134635.2 |
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