Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

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© 2019 The Authors The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal epithelium leads to highly penetrant metastasis (100% metastasis; with >80% liver metastases) in K...

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Bibliographic Details
Main Authors: Jackstadt, Rene, van Hooff, Sander R, Leach, Joshua D, Cortes-Lavaud, Xabier, Lohuis, Jeroen O, Ridgway, Rachel A, Wouters, Valérie M, Roper, Jatin, Kendall, Timothy J, Roxburgh, Campbell S, Horgan, Paul G, Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H, Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V, Campbell, Andrew D, Adams, David J, Barry, Simon T, Steele, Colin W, Medema, Jan Paul, Sansom, Owen J
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/134648

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