Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP

Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP

Motivation: TRAIL has been widely studied for the ability to kill cancer cells selectively, but its clinical usefulness has been hindered by the development of resistance. Multiple compounds have been identified that sensitize cancer cells to TRAIL-induced apoptosis. The drug LY303511 (LY30), combin...

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Bibliographic Details
Main Authors:	Shi, Y, Mellier, G, Huang, S, White, J, Pervaiz, S, Tucker-Kellogg, L
Other Authors:	Singapore-MIT Alliance in Research and Technology (SMART)
Format:	Article
Language:	English
Published:	Oxford University Press (OUP) 2021
Online Access:	https://hdl.handle.net/1721.1/134649

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