Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: Mammoplasty removes random samples of breast tissue from asymptomatic women providing a unique method for evaluating background prevalence of breast pathology in normal population. Our goal was to identify the rate of at...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2021
|
| Online Access: | https://hdl.handle.net/1721.1/134753 |
| _version_ | 1826198636692766720 |
|---|---|
| author | Acevedo, Francisco Armengol, V Diego Deng, Zhengyi Tang, Rong Coopey, Suzanne B Braun, Danielle Yala, Adam Barzilay, Regina Li, Clara Colwell, Amy Guidi, Anthony Cetrulo, Curtis L Garber, Judy Smith, Barbara L King, Tari Hughes, Kevin S |
| author_facet | Acevedo, Francisco Armengol, V Diego Deng, Zhengyi Tang, Rong Coopey, Suzanne B Braun, Danielle Yala, Adam Barzilay, Regina Li, Clara Colwell, Amy Guidi, Anthony Cetrulo, Curtis L Garber, Judy Smith, Barbara L King, Tari Hughes, Kevin S |
| author_sort | Acevedo, Francisco |
| collection | MIT |
| description | © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: Mammoplasty removes random samples of breast tissue from asymptomatic women providing a unique method for evaluating background prevalence of breast pathology in normal population. Our goal was to identify the rate of atypical breast lesions and cancers in women of various ages in the largest mammoplasty cohort reported to date. Methods: We analyzed pathologic reports from patients undergoing bilateral mammoplasty, using natural language processing algorithm, verified by human review. Patients with a prior history of breast cancer or atypia were excluded. Results: A total of 4775 patients were deemed eligible. Median age was 40 (range 13–86) and was higher in patients with any incidental finding compared to patients with normal reports (52 vs. 39 years, p = 0.0001). Pathological findings were detected in 7.06% (337) of procedures. Benign high-risk lesions were found in 299 patients (6.26%). Invasive carcinoma and ductal carcinoma in situ were detected in 15 (0.31%) and 23 (0.48%) patients, respectively. The rate of atypias and cancers increased with age. Conclusion: The overall rate of abnormal findings in asymptomatic patients undergoing mammoplasty was 7.06%, increasing with age. As these results are based on random sample of breast tissue, they likely underestimate the prevalence of abnormal findings in asymptomatic women. |
| first_indexed | 2024-09-23T11:07:52Z |
| format | Article |
| id | mit-1721.1/134753 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:07:52Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | mit-1721.1/1347532021-10-28T04:21:50Z Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions Acevedo, Francisco Armengol, V Diego Deng, Zhengyi Tang, Rong Coopey, Suzanne B Braun, Danielle Yala, Adam Barzilay, Regina Li, Clara Colwell, Amy Guidi, Anthony Cetrulo, Curtis L Garber, Judy Smith, Barbara L King, Tari Hughes, Kevin S © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: Mammoplasty removes random samples of breast tissue from asymptomatic women providing a unique method for evaluating background prevalence of breast pathology in normal population. Our goal was to identify the rate of atypical breast lesions and cancers in women of various ages in the largest mammoplasty cohort reported to date. Methods: We analyzed pathologic reports from patients undergoing bilateral mammoplasty, using natural language processing algorithm, verified by human review. Patients with a prior history of breast cancer or atypia were excluded. Results: A total of 4775 patients were deemed eligible. Median age was 40 (range 13–86) and was higher in patients with any incidental finding compared to patients with normal reports (52 vs. 39 years, p = 0.0001). Pathological findings were detected in 7.06% (337) of procedures. Benign high-risk lesions were found in 299 patients (6.26%). Invasive carcinoma and ductal carcinoma in situ were detected in 15 (0.31%) and 23 (0.48%) patients, respectively. The rate of atypias and cancers increased with age. Conclusion: The overall rate of abnormal findings in asymptomatic patients undergoing mammoplasty was 7.06%, increasing with age. As these results are based on random sample of breast tissue, they likely underestimate the prevalence of abnormal findings in asymptomatic women. 2021-10-27T20:08:58Z 2021-10-27T20:08:58Z 2019 2019-09-17T12:52:54Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134753 en 10.1007/S10549-018-4962-0 Breast Cancer Research and Treatment Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Nature Other repository |
| spellingShingle | Acevedo, Francisco Armengol, V Diego Deng, Zhengyi Tang, Rong Coopey, Suzanne B Braun, Danielle Yala, Adam Barzilay, Regina Li, Clara Colwell, Amy Guidi, Anthony Cetrulo, Curtis L Garber, Judy Smith, Barbara L King, Tari Hughes, Kevin S Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions |
| title | Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions |
| title_full | Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions |
| title_fullStr | Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions |
| title_full_unstemmed | Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions |
| title_short | Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions |
| title_sort | pathologic findings in reduction mammoplasty specimens a surrogate for the population prevalence of breast cancer and high risk lesions |
| url | https://hdl.handle.net/1721.1/134753 |
| work_keys_str_mv | AT acevedofrancisco pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT armengolvdiego pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT dengzhengyi pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT tangrong pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT coopeysuzanneb pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT braundanielle pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT yalaadam pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT barzilayregina pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT liclara pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT colwellamy pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT guidianthony pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT cetrulocurtisl pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT garberjudy pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT smithbarbaral pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT kingtari pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions AT hugheskevins pathologicfindingsinreductionmammoplastyspecimensasurrogateforthepopulationprevalenceofbreastcancerandhighrisklesions |