Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process
© 2019, The Author(s). Thermoresponsive nanoemulsions find utility in applications ranging from food to pharmaceuticals to consumer products. Prior systems have found limited translation to applications due to cytotoxicity of the compositions and/or difficulties in scaling-up the process. Here, we r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/134773 |
| _version_ | 1826217226001186816 |
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| author | Hashemnejad, Seyed Meysam Badruddoza, Abu Zayed Md Zarket, Brady Ricardo Castaneda, Carlos Doyle, Patrick S |
| author_facet | Hashemnejad, Seyed Meysam Badruddoza, Abu Zayed Md Zarket, Brady Ricardo Castaneda, Carlos Doyle, Patrick S |
| author_sort | Hashemnejad, Seyed Meysam |
| collection | MIT |
| description | © 2019, The Author(s). Thermoresponsive nanoemulsions find utility in applications ranging from food to pharmaceuticals to consumer products. Prior systems have found limited translation to applications due to cytotoxicity of the compositions and/or difficulties in scaling-up the process. Here, we report a route to thermally gel an oil-in-water nanoemulsion using a small amount of FDA-approved amphiphilic triblock Pluronic copolymers which act as gelling agents. At ambient temperature the suspension displays liquid-like behavior, and quickly becomes an elastic gel at elevated temperatures. We propose a gelation mechanism triggered by synergistic action of thermally-induced adsorption of Pluronic copolymers onto the droplet interface and an increased micelle concentration in the aqueous solution. We demonstrate that the system’s properties can be tuned via many factors and report their rheological properties. The nanoemulsions are prepared using a low-energy process which offers an efficient route to scale-up. The nanoemulsion formulations are well-suited for use in cosmetics and pharmaceutical applications. |
| first_indexed | 2024-09-23T16:59:58Z |
| format | Article |
| id | mit-1721.1/134773 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:59:58Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1347732022-03-30T14:46:46Z Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process Hashemnejad, Seyed Meysam Badruddoza, Abu Zayed Md Zarket, Brady Ricardo Castaneda, Carlos Doyle, Patrick S © 2019, The Author(s). Thermoresponsive nanoemulsions find utility in applications ranging from food to pharmaceuticals to consumer products. Prior systems have found limited translation to applications due to cytotoxicity of the compositions and/or difficulties in scaling-up the process. Here, we report a route to thermally gel an oil-in-water nanoemulsion using a small amount of FDA-approved amphiphilic triblock Pluronic copolymers which act as gelling agents. At ambient temperature the suspension displays liquid-like behavior, and quickly becomes an elastic gel at elevated temperatures. We propose a gelation mechanism triggered by synergistic action of thermally-induced adsorption of Pluronic copolymers onto the droplet interface and an increased micelle concentration in the aqueous solution. We demonstrate that the system’s properties can be tuned via many factors and report their rheological properties. The nanoemulsions are prepared using a low-energy process which offers an efficient route to scale-up. The nanoemulsion formulations are well-suited for use in cosmetics and pharmaceutical applications. 2021-10-27T20:09:06Z 2021-10-27T20:09:06Z 2019 2019-08-16T18:18:52Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134773 en 10.1038/s41467-019-10749-1 Nature Communications Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Nature |
| spellingShingle | Hashemnejad, Seyed Meysam Badruddoza, Abu Zayed Md Zarket, Brady Ricardo Castaneda, Carlos Doyle, Patrick S Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process |
| title | Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process |
| title_full | Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process |
| title_fullStr | Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process |
| title_full_unstemmed | Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process |
| title_short | Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process |
| title_sort | thermoresponsive nanoemulsion based gel synthesized through a low energy process |
| url | https://hdl.handle.net/1721.1/134773 |
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