The development of bioresorbable composite polymeric implants with high mechanical strength
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Implants for the treatment of tissue defects should mimic the mechanical properties of the native tissue of interest and should be resorbable as well as biocompatible. In this work, we developed a scaffold from varian...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2021
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| Online Access: | https://hdl.handle.net/1721.1/134880 |
| _version_ | 1826210576189095936 |
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| author | Sharma, Upma Concagh, Danny Core, Lee Kuang, Yina You, Changcheng Pham, Quynh Zugates, Greg Busold, Rany Webber, Stephanie Merlo, Jonathan Langer, Robert Whitesides, George M Palasis, Maria |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Sharma, Upma Concagh, Danny Core, Lee Kuang, Yina You, Changcheng Pham, Quynh Zugates, Greg Busold, Rany Webber, Stephanie Merlo, Jonathan Langer, Robert Whitesides, George M Palasis, Maria |
| author_sort | Sharma, Upma |
| collection | MIT |
| description | © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Implants for the treatment of tissue defects should mimic the mechanical properties of the native tissue of interest and should be resorbable as well as biocompatible. In this work, we developed a scaffold from variants of poly(glycolic) acid which were braided and coated with an elastomer of poly(glycolide-co-caprolactone) and crosslinked. The coating of the scaffold with the elastomer led to higher mechanical strength in terms of compression, expansion and elasticity compared to braids without the elastomer coating. These composite scaffolds were found to have expansion properties similar to metallic stents, utilizing materials which are typically much weaker than metal. We optimized the mechanical properties of the implant by tuning the elastomer branching structure, crosslink density, and molecular weight. The scaffolds were shown to be highly resorbable following implantation in a porcine femoral artery. Biocompatibility was studied in vivo in an ovine model by implanting the scaffolds into femoral arteries. The scaffolds were able to support an expanded open lumen over 12 months in vivo and also fully resorbed by 18 months in the ovine model. |
| first_indexed | 2024-09-23T14:52:10Z |
| format | Article |
| id | mit-1721.1/134880 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:52:10Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | mit-1721.1/1348802023-02-24T17:56:43Z The development of bioresorbable composite polymeric implants with high mechanical strength Sharma, Upma Concagh, Danny Core, Lee Kuang, Yina You, Changcheng Pham, Quynh Zugates, Greg Busold, Rany Webber, Stephanie Merlo, Jonathan Langer, Robert Whitesides, George M Palasis, Maria Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Implants for the treatment of tissue defects should mimic the mechanical properties of the native tissue of interest and should be resorbable as well as biocompatible. In this work, we developed a scaffold from variants of poly(glycolic) acid which were braided and coated with an elastomer of poly(glycolide-co-caprolactone) and crosslinked. The coating of the scaffold with the elastomer led to higher mechanical strength in terms of compression, expansion and elasticity compared to braids without the elastomer coating. These composite scaffolds were found to have expansion properties similar to metallic stents, utilizing materials which are typically much weaker than metal. We optimized the mechanical properties of the implant by tuning the elastomer branching structure, crosslink density, and molecular weight. The scaffolds were shown to be highly resorbable following implantation in a porcine femoral artery. Biocompatibility was studied in vivo in an ovine model by implanting the scaffolds into femoral arteries. The scaffolds were able to support an expanded open lumen over 12 months in vivo and also fully resorbed by 18 months in the ovine model. 2021-10-27T20:09:38Z 2021-10-27T20:09:38Z 2018 2019-09-03T16:58:42Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134880 en 10.1038/NMAT5016 Nature Materials Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Springer Nature Other repository |
| spellingShingle | Sharma, Upma Concagh, Danny Core, Lee Kuang, Yina You, Changcheng Pham, Quynh Zugates, Greg Busold, Rany Webber, Stephanie Merlo, Jonathan Langer, Robert Whitesides, George M Palasis, Maria The development of bioresorbable composite polymeric implants with high mechanical strength |
| title | The development of bioresorbable composite polymeric implants with high mechanical strength |
| title_full | The development of bioresorbable composite polymeric implants with high mechanical strength |
| title_fullStr | The development of bioresorbable composite polymeric implants with high mechanical strength |
| title_full_unstemmed | The development of bioresorbable composite polymeric implants with high mechanical strength |
| title_short | The development of bioresorbable composite polymeric implants with high mechanical strength |
| title_sort | development of bioresorbable composite polymeric implants with high mechanical strength |
| url | https://hdl.handle.net/1721.1/134880 |
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