Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering
© 2017 The Authors Glycosylated lipids (GLs) are added-value lipid derivatives of great potential. Besides their interesting surface activities that qualify many of them to act as excellent ecological detergents, they have diverse biological activities with promising biomedical and cosmeceutical app...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/134982 |
| _version_ | 1811077644949651456 |
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| author | Abdel-Mawgoud, Ahmad Mohammad Stephanopoulos, Gregory |
| author_facet | Abdel-Mawgoud, Ahmad Mohammad Stephanopoulos, Gregory |
| author_sort | Abdel-Mawgoud, Ahmad Mohammad |
| collection | MIT |
| description | © 2017 The Authors Glycosylated lipids (GLs) are added-value lipid derivatives of great potential. Besides their interesting surface activities that qualify many of them to act as excellent ecological detergents, they have diverse biological activities with promising biomedical and cosmeceutical applications. Glycolipids, especially those of microbial origin, have interesting antimicrobial, anticancer, antiparasitic as well as immunomodulatory activities. Nonetheless, GLs are hardly accessing the market because of their high cost of production. We believe that experience of metabolic engineering (ME) of microbial lipids for biofuel production can now be harnessed towards a successful synthesis of microbial GLs for biomedical and other applications. This review presents chemical groups of bacterial and fungal GLs, their biological activities, their general biosynthetic pathways and an insight on ME strategies for their production. |
| first_indexed | 2024-09-23T10:46:19Z |
| format | Article |
| id | mit-1721.1/134982 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:46:19Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1349822022-03-29T20:31:59Z Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering Abdel-Mawgoud, Ahmad Mohammad Stephanopoulos, Gregory © 2017 The Authors Glycosylated lipids (GLs) are added-value lipid derivatives of great potential. Besides their interesting surface activities that qualify many of them to act as excellent ecological detergents, they have diverse biological activities with promising biomedical and cosmeceutical applications. Glycolipids, especially those of microbial origin, have interesting antimicrobial, anticancer, antiparasitic as well as immunomodulatory activities. Nonetheless, GLs are hardly accessing the market because of their high cost of production. We believe that experience of metabolic engineering (ME) of microbial lipids for biofuel production can now be harnessed towards a successful synthesis of microbial GLs for biomedical and other applications. This review presents chemical groups of bacterial and fungal GLs, their biological activities, their general biosynthetic pathways and an insight on ME strategies for their production. 2021-10-27T20:10:10Z 2021-10-27T20:10:10Z 2018 2019-09-12T13:52:10Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134982 en 10.1016/J.SYNBIO.2017.12.001 Synthetic and Systems Biotechnology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Abdel-Mawgoud, Ahmad Mohammad Stephanopoulos, Gregory Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering |
| title | Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering |
| title_full | Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering |
| title_fullStr | Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering |
| title_full_unstemmed | Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering |
| title_short | Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering |
| title_sort | simple glycolipids of microbes chemistry biological activity and metabolic engineering |
| url | https://hdl.handle.net/1721.1/134982 |
| work_keys_str_mv | AT abdelmawgoudahmadmohammad simpleglycolipidsofmicrobeschemistrybiologicalactivityandmetabolicengineering AT stephanopoulosgregory simpleglycolipidsofmicrobeschemistrybiologicalactivityandmetabolicengineering |