In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI
© 2016, ESMRMB. Objective: Our aim was to map the in vivo human functional connectivity of several brainstem nuclei with the rest of the brain by using seed-based correlation of ultra-high magnetic field functional magnetic resonance imaging (fMRI) data. Materials and methods: We used the recently d...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/134987 |
| _version_ | 1811094509056950272 |
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| author | Bianciardi, Marta Toschi, Nicola Eichner, Cornelius Polimeni, Jonathan R Setsompop, Kawin Brown, Emery N Hämäläinen, Matti S Rosen, Bruce R Wald, Lawrence L |
| author2 | Martinos Imaging Center (McGovern Institute for Brain Research at MIT) |
| author_facet | Martinos Imaging Center (McGovern Institute for Brain Research at MIT) Bianciardi, Marta Toschi, Nicola Eichner, Cornelius Polimeni, Jonathan R Setsompop, Kawin Brown, Emery N Hämäläinen, Matti S Rosen, Bruce R Wald, Lawrence L |
| author_sort | Bianciardi, Marta |
| collection | MIT |
| description | © 2016, ESMRMB. Objective: Our aim was to map the in vivo human functional connectivity of several brainstem nuclei with the rest of the brain by using seed-based correlation of ultra-high magnetic field functional magnetic resonance imaging (fMRI) data. Materials and methods: We used the recently developed template of 11 brainstem nuclei derived from multi-contrast structural MRI at 7 Tesla as seed regions to determine their connectivity to the rest of the brain. To achieve this, we used the increased contrast-to-noise ratio of 7-Tesla fMRI compared with 3 Tesla and time-efficient simultaneous multi-slice imaging to cover the brain with high spatial resolution (1.1-mm isotropic nominal resolution) while maintaining a short repetition time (2.5 s). Results: The delineated Pearson’s correlation-based functional connectivity diagrams (connectomes) of 11 brainstem nuclei of the ascending arousal, motor, and autonomic systems from 12 controls are presented and discussed in the context of existing histology and animal work. Conclusion: Considering that the investigated brainstem nuclei play a crucial role in several vital functions, the delineated preliminary connectomes might prove useful for future in vivo research and clinical studies of human brainstem function and pathology, including disorders of consciousness, sleep disorders, autonomic disorders, Parkinson’s disease, and other motor disorders. |
| first_indexed | 2024-09-23T16:01:27Z |
| format | Article |
| id | mit-1721.1/134987 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:01:27Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1349872023-01-20T21:51:17Z In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI Bianciardi, Marta Toschi, Nicola Eichner, Cornelius Polimeni, Jonathan R Setsompop, Kawin Brown, Emery N Hämäläinen, Matti S Rosen, Bruce R Wald, Lawrence L Martinos Imaging Center (McGovern Institute for Brain Research at MIT) © 2016, ESMRMB. Objective: Our aim was to map the in vivo human functional connectivity of several brainstem nuclei with the rest of the brain by using seed-based correlation of ultra-high magnetic field functional magnetic resonance imaging (fMRI) data. Materials and methods: We used the recently developed template of 11 brainstem nuclei derived from multi-contrast structural MRI at 7 Tesla as seed regions to determine their connectivity to the rest of the brain. To achieve this, we used the increased contrast-to-noise ratio of 7-Tesla fMRI compared with 3 Tesla and time-efficient simultaneous multi-slice imaging to cover the brain with high spatial resolution (1.1-mm isotropic nominal resolution) while maintaining a short repetition time (2.5 s). Results: The delineated Pearson’s correlation-based functional connectivity diagrams (connectomes) of 11 brainstem nuclei of the ascending arousal, motor, and autonomic systems from 12 controls are presented and discussed in the context of existing histology and animal work. Conclusion: Considering that the investigated brainstem nuclei play a crucial role in several vital functions, the delineated preliminary connectomes might prove useful for future in vivo research and clinical studies of human brainstem function and pathology, including disorders of consciousness, sleep disorders, autonomic disorders, Parkinson’s disease, and other motor disorders. 2021-10-27T20:10:11Z 2021-10-27T20:10:11Z 2016 2021-04-28T16:40:11Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134987 en 10.1007/S10334-016-0546-3 Magnetic Resonance Materials in Physics, Biology and Medicine Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Science and Business Media LLC PMC |
| spellingShingle | Bianciardi, Marta Toschi, Nicola Eichner, Cornelius Polimeni, Jonathan R Setsompop, Kawin Brown, Emery N Hämäläinen, Matti S Rosen, Bruce R Wald, Lawrence L In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI |
| title | In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI |
| title_full | In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI |
| title_fullStr | In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI |
| title_full_unstemmed | In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI |
| title_short | In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI |
| title_sort | in vivo functional connectome of human brainstem nuclei of the ascending arousal autonomic and motor systems by high spatial resolution 7 tesla fmri |
| url | https://hdl.handle.net/1721.1/134987 |
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