Caffeine-catalyzed gels
© 2018 The Authors Covalently cross-linked gels are utilized in a broad range of biomedical applications though their synthesis often compromises easy implementation. Cross-linking reactions commonly utilize catalysts or conditions that can damage biologics and sensitive compounds, producing materia...
| Main Authors: | , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
|
| Online Access: | https://hdl.handle.net/1721.1/135015 |
| _version_ | 1826217246296375296 |
|---|---|
| author | DiCiccio, Angela M Lee, Young-Ah Lucy Glettig, Dean L Walton, Elizabeth SE de la Serna, Eva L Montgomery, Veronica A Grant, Tyler M Langer, Robert Traverso, Giovanni |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering DiCiccio, Angela M Lee, Young-Ah Lucy Glettig, Dean L Walton, Elizabeth SE de la Serna, Eva L Montgomery, Veronica A Grant, Tyler M Langer, Robert Traverso, Giovanni |
| author_sort | DiCiccio, Angela M |
| collection | MIT |
| description | © 2018 The Authors Covalently cross-linked gels are utilized in a broad range of biomedical applications though their synthesis often compromises easy implementation. Cross-linking reactions commonly utilize catalysts or conditions that can damage biologics and sensitive compounds, producing materials that require extensive post processing to achieve acceptable biocompatibility. As an alternative, we report a batch synthesis platform to produce covalently cross-linked materials appropriate for direct biomedical application enabled by green chemistry and commonly available food grade ingredients. Using caffeine, a mild base, to catalyze anhydrous carboxylate ring-opening of diglycidyl-ether functionalized monomers with citric acid as a tri-functional crosslinking agent we introduce a novel poly(ester-ether) gel synthesis platform. We demonstrate that biocompatible Caffeine Catalyzed Gels (CCGs) exhibit dynamic physical, chemical, and mechanical properties, which can be tailored in shape, surface texture, solvent response, cargo release, shear and tensile strength, among other potential attributes. The demonstrated versatility, low cost and facile synthesis of these CCGs renders them appropriate for a broad range of customized engineering applications including drug delivery constructs, tissue engineering scaffolds, and medical devices. |
| first_indexed | 2024-09-23T17:00:20Z |
| format | Article |
| id | mit-1721.1/135015 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T17:00:20Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1350152023-03-24T17:36:58Z Caffeine-catalyzed gels DiCiccio, Angela M Lee, Young-Ah Lucy Glettig, Dean L Walton, Elizabeth SE de la Serna, Eva L Montgomery, Veronica A Grant, Tyler M Langer, Robert Traverso, Giovanni Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT © 2018 The Authors Covalently cross-linked gels are utilized in a broad range of biomedical applications though their synthesis often compromises easy implementation. Cross-linking reactions commonly utilize catalysts or conditions that can damage biologics and sensitive compounds, producing materials that require extensive post processing to achieve acceptable biocompatibility. As an alternative, we report a batch synthesis platform to produce covalently cross-linked materials appropriate for direct biomedical application enabled by green chemistry and commonly available food grade ingredients. Using caffeine, a mild base, to catalyze anhydrous carboxylate ring-opening of diglycidyl-ether functionalized monomers with citric acid as a tri-functional crosslinking agent we introduce a novel poly(ester-ether) gel synthesis platform. We demonstrate that biocompatible Caffeine Catalyzed Gels (CCGs) exhibit dynamic physical, chemical, and mechanical properties, which can be tailored in shape, surface texture, solvent response, cargo release, shear and tensile strength, among other potential attributes. The demonstrated versatility, low cost and facile synthesis of these CCGs renders them appropriate for a broad range of customized engineering applications including drug delivery constructs, tissue engineering scaffolds, and medical devices. 2021-10-27T20:10:19Z 2021-10-27T20:10:19Z 2018 2019-09-06T19:52:02Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135015 en 10.1016/J.BIOMATERIALS.2018.04.010 Biomaterials Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | DiCiccio, Angela M Lee, Young-Ah Lucy Glettig, Dean L Walton, Elizabeth SE de la Serna, Eva L Montgomery, Veronica A Grant, Tyler M Langer, Robert Traverso, Giovanni Caffeine-catalyzed gels |
| title | Caffeine-catalyzed gels |
| title_full | Caffeine-catalyzed gels |
| title_fullStr | Caffeine-catalyzed gels |
| title_full_unstemmed | Caffeine-catalyzed gels |
| title_short | Caffeine-catalyzed gels |
| title_sort | caffeine catalyzed gels |
| url | https://hdl.handle.net/1721.1/135015 |
| work_keys_str_mv | AT diciccioangelam caffeinecatalyzedgels AT leeyoungahlucy caffeinecatalyzedgels AT glettigdeanl caffeinecatalyzedgels AT waltonelizabethse caffeinecatalyzedgels AT delasernaeval caffeinecatalyzedgels AT montgomeryveronicaa caffeinecatalyzedgels AT granttylerm caffeinecatalyzedgels AT langerrobert caffeinecatalyzedgels AT traversogiovanni caffeinecatalyzedgels |