Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition
© 2019 Elsevier Inc. We previously reported that inducing gamma oscillations with a non-invasive light flicker (gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual cortex of Alzheimer's disease mouse models. Here, we designed auditory tone stimulation that drove...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/135092 |
| _version_ | 1826201865258270720 |
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| author | Martorell, Anthony J Paulson, Abigail L Suk, Ho-Jun Abdurrob, Fatema Drummond, Gabrielle T Guan, Webster Young, Jennie Z Kim, David Nam-Woo Kritskiy, Oleg Barker, Scarlett J Mangena, Vamsi Prince, Stephanie M Brown, Emery N Chung, Kwanghun Boyden, Edward S Singer, Annabelle C Tsai, Li-Huei |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Martorell, Anthony J Paulson, Abigail L Suk, Ho-Jun Abdurrob, Fatema Drummond, Gabrielle T Guan, Webster Young, Jennie Z Kim, David Nam-Woo Kritskiy, Oleg Barker, Scarlett J Mangena, Vamsi Prince, Stephanie M Brown, Emery N Chung, Kwanghun Boyden, Edward S Singer, Annabelle C Tsai, Li-Huei |
| author_sort | Martorell, Anthony J |
| collection | MIT |
| description | © 2019 Elsevier Inc. We previously reported that inducing gamma oscillations with a non-invasive light flicker (gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual cortex of Alzheimer's disease mouse models. Here, we designed auditory tone stimulation that drove gamma frequency neural activity in auditory cortex (AC) and hippocampal CA1. Seven days of auditory GENUS improved spatial and recognition memory and reduced amyloid in AC and hippocampus of 5XFAD mice. Changes in activation responses were evident in microglia, astrocytes, and vasculature. Auditory GENUS also reduced phosphorylated tau in the P301S tauopathy model. Furthermore, combined auditory and visual GENUS, but not either alone, produced microglial-clustering responses, and decreased amyloid in medial prefrontal cortex. Whole brain analysis using SHIELD revealed widespread reduction of amyloid plaques throughout neocortex after multi-sensory GENUS. Thus, GENUS can be achieved through multiple sensory modalities with wide-ranging effects across multiple brain areas to improve cognitive function. Auditory stimulation combined with light-induced gamma oscillations in the hippocampus CA1 and auditory cortex regions of the brain reduces amyloid levels and improves memory in animal models of Alzheimer's disease. |
| first_indexed | 2024-09-23T11:58:25Z |
| format | Article |
| id | mit-1721.1/135092 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:58:25Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1350922024-03-20T19:13:09Z Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition Martorell, Anthony J Paulson, Abigail L Suk, Ho-Jun Abdurrob, Fatema Drummond, Gabrielle T Guan, Webster Young, Jennie Z Kim, David Nam-Woo Kritskiy, Oleg Barker, Scarlett J Mangena, Vamsi Prince, Stephanie M Brown, Emery N Chung, Kwanghun Boyden, Edward S Singer, Annabelle C Tsai, Li-Huei Picower Institute for Learning and Memory Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Media Laboratory Massachusetts Institute of Technology. Department of Biological Engineering Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Institute for Medical Engineering & Science © 2019 Elsevier Inc. We previously reported that inducing gamma oscillations with a non-invasive light flicker (gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual cortex of Alzheimer's disease mouse models. Here, we designed auditory tone stimulation that drove gamma frequency neural activity in auditory cortex (AC) and hippocampal CA1. Seven days of auditory GENUS improved spatial and recognition memory and reduced amyloid in AC and hippocampus of 5XFAD mice. Changes in activation responses were evident in microglia, astrocytes, and vasculature. Auditory GENUS also reduced phosphorylated tau in the P301S tauopathy model. Furthermore, combined auditory and visual GENUS, but not either alone, produced microglial-clustering responses, and decreased amyloid in medial prefrontal cortex. Whole brain analysis using SHIELD revealed widespread reduction of amyloid plaques throughout neocortex after multi-sensory GENUS. Thus, GENUS can be achieved through multiple sensory modalities with wide-ranging effects across multiple brain areas to improve cognitive function. Auditory stimulation combined with light-induced gamma oscillations in the hippocampus CA1 and auditory cortex regions of the brain reduces amyloid levels and improves memory in animal models of Alzheimer's disease. 2021-10-27T20:10:41Z 2021-10-27T20:10:41Z 2019 2021-06-08T18:19:02Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135092 en 10.1016/J.CELL.2019.02.014 Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Martorell, Anthony J Paulson, Abigail L Suk, Ho-Jun Abdurrob, Fatema Drummond, Gabrielle T Guan, Webster Young, Jennie Z Kim, David Nam-Woo Kritskiy, Oleg Barker, Scarlett J Mangena, Vamsi Prince, Stephanie M Brown, Emery N Chung, Kwanghun Boyden, Edward S Singer, Annabelle C Tsai, Li-Huei Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition |
| title | Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition |
| title_full | Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition |
| title_fullStr | Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition |
| title_full_unstemmed | Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition |
| title_short | Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition |
| title_sort | multi sensory gamma stimulation ameliorates alzheimer s associated pathology and improves cognition |
| url | https://hdl.handle.net/1721.1/135092 |
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