RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

© 2019 Elsevier Inc. Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Wesselhoeft, R Alexander, Kowalski, Piotr S, Parker-Hale, Frances C, Huang, Yuxuan, Bisaria, Namita, Anderson, Daniel G
Kolejni autorzy: Koch Institute for Integrative Cancer Research at MIT
Format: Artykuł
Język:English
Wydane: Elsevier BV 2021
Dostęp online:https://hdl.handle.net/1721.1/135094
Opis
Streszczenie:© 2019 Elsevier Inc. Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression.