RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo
© 2019 Elsevier Inc. Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/135094 |
| _version_ | 1826214767750021120 |
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| author | Wesselhoeft, R Alexander Kowalski, Piotr S Parker-Hale, Frances C Huang, Yuxuan Bisaria, Namita Anderson, Daniel G |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Wesselhoeft, R Alexander Kowalski, Piotr S Parker-Hale, Frances C Huang, Yuxuan Bisaria, Namita Anderson, Daniel G |
| author_sort | Wesselhoeft, R Alexander |
| collection | MIT |
| description | © 2019 Elsevier Inc. Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression. |
| first_indexed | 2024-09-23T16:10:50Z |
| format | Article |
| id | mit-1721.1/135094 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:10:50Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1350942024-03-20T19:07:10Z RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo Wesselhoeft, R Alexander Kowalski, Piotr S Parker-Hale, Frances C Huang, Yuxuan Bisaria, Namita Anderson, Daniel G Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Political Science Whitehead Institute for Biomedical Research Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology © 2019 Elsevier Inc. Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression. 2021-10-27T20:10:42Z 2021-10-27T20:10:42Z 2019 2021-06-02T18:57:59Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135094 en 10.1016/J.MOLCEL.2019.02.015 Molecular Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Wesselhoeft, R Alexander Kowalski, Piotr S Parker-Hale, Frances C Huang, Yuxuan Bisaria, Namita Anderson, Daniel G RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo |
| title | RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo |
| title_full | RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo |
| title_fullStr | RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo |
| title_full_unstemmed | RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo |
| title_short | RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo |
| title_sort | rna circularization diminishes immunogenicity and can extend translation duration in vivo |
| url | https://hdl.handle.net/1721.1/135094 |
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