RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

© 2019 Elsevier Inc. Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the...

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Bibliographic Details
Main Authors:	Wesselhoeft, R Alexander, Kowalski, Piotr S, Parker-Hale, Frances C, Huang, Yuxuan, Bisaria, Namita, Anderson, Daniel G
Other Authors:	Koch Institute for Integrative Cancer Research at MIT
Format:	Article
Language:	English
Published:	Elsevier BV 2021
Online Access:	https://hdl.handle.net/1721.1/135094

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