Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy

Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy

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© 2019 National Academy of Sciences. All rights reserved. Cancer-associated fibroblasts (CAFs) can either suppress or support T lymphocyte activity, suggesting that CAFs may be reprogrammable to an immunosupportive state. Angiotensin receptor blockers (ARBs) convert myofibroblast CAFs to a quiescent...

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Bibliographic Details
Main Authors: Chauhan, Vikash P, Chen, Ivy X, Tong, Rong, Ng, Mei Rosa, Martin, John D, Naxerova, Kamila, Wu, Michelle W, Huang, Peigen, Boucher, Yves, Kohane, Daniel S, Langer, Robert, Jain, Rakesh K
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2021
Online Access:https://hdl.handle.net/1721.1/135170

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https://hdl.handle.net/1721.1/135170

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