Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

Copyright © 2020 Meilandt et al. TREM2 is an Alzheimer’s disease (AD) risk gene expressed in microglia. To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2 ko) at ages ranging from 4 to 22 months. Microgliosi...

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Main Authors:	Meilandt, William J., Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J., Stark, Kimberly L., Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A., Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V.
Other Authors:	Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format:	Article
Language:	English
Published:	Society for Neuroscience 2022
Online Access:	https://hdl.handle.net/1721.1/135187.2

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mou... by Meilandt, William J, Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J, Stark, Kimberly L, Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A, Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V

Published 2021

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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

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