GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models
Hanson et al. examine the therapeutic effects of enhancing GluN2A-subunit-containing NMDAR function in Dravet syndrome and Alzheimer's disease mice. GNE-0723 treatment reduces aberrant low-frequency oscillations and epileptiform discharges and improves cognitive functions in both disease models...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/135208 |
| _version_ | 1826196514647572480 |
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| author | Hanson, Jesse E Ma, Keran Elstrott, Justin Weber, Martin Saillet, Sandrine Khan, Abdullah S Simms, Jeffrey Liu, Benjamin Kim, Thomas A Yu, Gui-Qiu Chen, Yelin Wang, Tzu-Ming Jiang, Zhiyu Liederer, Bianca M Deshmukh, Gauri Solanoy, Hilda Chan, Connie Sellers, Benjamin D Volgraf, Matthew Schwarz, Jacob B Hackos, David H Weimer, Robby M Sheng, Morgan Gill, T Michael Scearce-Levie, Kimberly Palop, Jorge J |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Hanson, Jesse E Ma, Keran Elstrott, Justin Weber, Martin Saillet, Sandrine Khan, Abdullah S Simms, Jeffrey Liu, Benjamin Kim, Thomas A Yu, Gui-Qiu Chen, Yelin Wang, Tzu-Ming Jiang, Zhiyu Liederer, Bianca M Deshmukh, Gauri Solanoy, Hilda Chan, Connie Sellers, Benjamin D Volgraf, Matthew Schwarz, Jacob B Hackos, David H Weimer, Robby M Sheng, Morgan Gill, T Michael Scearce-Levie, Kimberly Palop, Jorge J |
| author_sort | Hanson, Jesse E |
| collection | MIT |
| description | Hanson et al. examine the therapeutic effects of enhancing GluN2A-subunit-containing NMDAR function in Dravet syndrome and Alzheimer's disease mice. GNE-0723 treatment reduces aberrant low-frequency oscillations and epileptiform discharges and improves cognitive functions in both disease models. GluN2A NMDAR enhancers may benefit brain disorders with network hypersynchrony and cognitive impairments. |
| first_indexed | 2024-09-23T10:27:51Z |
| format | Article |
| id | mit-1721.1/135208 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:27:51Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1352082023-12-22T21:04:36Z GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models Hanson, Jesse E Ma, Keran Elstrott, Justin Weber, Martin Saillet, Sandrine Khan, Abdullah S Simms, Jeffrey Liu, Benjamin Kim, Thomas A Yu, Gui-Qiu Chen, Yelin Wang, Tzu-Ming Jiang, Zhiyu Liederer, Bianca M Deshmukh, Gauri Solanoy, Hilda Chan, Connie Sellers, Benjamin D Volgraf, Matthew Schwarz, Jacob B Hackos, David H Weimer, Robby M Sheng, Morgan Gill, T Michael Scearce-Levie, Kimberly Palop, Jorge J Picower Institute for Learning and Memory Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Hanson et al. examine the therapeutic effects of enhancing GluN2A-subunit-containing NMDAR function in Dravet syndrome and Alzheimer's disease mice. GNE-0723 treatment reduces aberrant low-frequency oscillations and epileptiform discharges and improves cognitive functions in both disease models. GluN2A NMDAR enhancers may benefit brain disorders with network hypersynchrony and cognitive impairments. 2021-10-27T20:22:28Z 2021-10-27T20:22:28Z 2020 2021-03-23T18:13:49Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135208 en 10.1016/J.CELREP.2019.12.030 Cell Reports Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Hanson, Jesse E Ma, Keran Elstrott, Justin Weber, Martin Saillet, Sandrine Khan, Abdullah S Simms, Jeffrey Liu, Benjamin Kim, Thomas A Yu, Gui-Qiu Chen, Yelin Wang, Tzu-Ming Jiang, Zhiyu Liederer, Bianca M Deshmukh, Gauri Solanoy, Hilda Chan, Connie Sellers, Benjamin D Volgraf, Matthew Schwarz, Jacob B Hackos, David H Weimer, Robby M Sheng, Morgan Gill, T Michael Scearce-Levie, Kimberly Palop, Jorge J GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models |
| title | GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models |
| title_full | GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models |
| title_fullStr | GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models |
| title_full_unstemmed | GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models |
| title_short | GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models |
| title_sort | glun2a nmda receptor enhancement improves brain oscillations synchrony and cognitive functions in dravet syndrome and alzheimer s disease models |
| url | https://hdl.handle.net/1721.1/135208 |
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