Polymer Nanocomposite Microactuators for On-Demand Chemical Release via High-Frequency Magnetic Field Excitation
On-demand delivery of substances has been demonstrated for various applications in the fields of chemistry and biomedical engineering. Single-pulse release profile has been shown previously for micro/nanoparticles in different form factors. However, to obtain a sustained release, a pulsatile release...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society (ACS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/135211 |
| _version_ | 1811094122998530048 |
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| author | Mirvakili, Seyed M Ngo, Quynh P Langer, Robert |
| author_facet | Mirvakili, Seyed M Ngo, Quynh P Langer, Robert |
| author_sort | Mirvakili, Seyed M |
| collection | MIT |
| description | On-demand delivery of substances has been demonstrated for various applications in the fields of chemistry and biomedical engineering. Single-pulse release profile has been shown previously for micro/nanoparticles in different form factors. However, to obtain a sustained release, a pulsatile release profile is needed. Here, we demonstrate such a release profile from polymer magnetic nanocomposite microspheres loaded with chemicals. By exciting the microactuators with AC magnetic fields, we could achieve up to 61% cumulative release over a five-day period. One of the main advantages of using a magnetic stimulus is that the properties of the environment (e.g., transparency, density, and depth) in which the particles are located do not affect the performance. The operating magnitude of the magnetic field used in this work is safe and does not interact with any nonmetallic materials. The proposed approach can potentially be used in microchemistry, drug delivery, lab-on-chip, and microrobots for drug delivery. |
| first_indexed | 2024-09-23T15:55:26Z |
| format | Article |
| id | mit-1721.1/135211 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:55:26Z |
| publishDate | 2021 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1352112021-10-28T03:16:41Z Polymer Nanocomposite Microactuators for On-Demand Chemical Release via High-Frequency Magnetic Field Excitation Mirvakili, Seyed M Ngo, Quynh P Langer, Robert On-demand delivery of substances has been demonstrated for various applications in the fields of chemistry and biomedical engineering. Single-pulse release profile has been shown previously for micro/nanoparticles in different form factors. However, to obtain a sustained release, a pulsatile release profile is needed. Here, we demonstrate such a release profile from polymer magnetic nanocomposite microspheres loaded with chemicals. By exciting the microactuators with AC magnetic fields, we could achieve up to 61% cumulative release over a five-day period. One of the main advantages of using a magnetic stimulus is that the properties of the environment (e.g., transparency, density, and depth) in which the particles are located do not affect the performance. The operating magnitude of the magnetic field used in this work is safe and does not interact with any nonmetallic materials. The proposed approach can potentially be used in microchemistry, drug delivery, lab-on-chip, and microrobots for drug delivery. 2021-10-27T20:22:30Z 2021-10-27T20:22:30Z 2020 2021-06-22T16:40:30Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135211 en 10.1021/ACS.NANOLETT.0C00648 Nano Letters Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | Mirvakili, Seyed M Ngo, Quynh P Langer, Robert Polymer Nanocomposite Microactuators for On-Demand Chemical Release via High-Frequency Magnetic Field Excitation |
| title | Polymer Nanocomposite Microactuators for On-Demand Chemical Release via High-Frequency Magnetic Field Excitation |
| title_full | Polymer Nanocomposite Microactuators for On-Demand Chemical Release via High-Frequency Magnetic Field Excitation |
| title_fullStr | Polymer Nanocomposite Microactuators for On-Demand Chemical Release via High-Frequency Magnetic Field Excitation |
| title_full_unstemmed | Polymer Nanocomposite Microactuators for On-Demand Chemical Release via High-Frequency Magnetic Field Excitation |
| title_short | Polymer Nanocomposite Microactuators for On-Demand Chemical Release via High-Frequency Magnetic Field Excitation |
| title_sort | polymer nanocomposite microactuators for on demand chemical release via high frequency magnetic field excitation |
| url | https://hdl.handle.net/1721.1/135211 |
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