How the T cell signaling network processes information to discriminate between self and agonist ligands

© 2020 National Academy of Sciences. All rights reserved. T cells exhibit remarkable sensitivity and selectivity in detecting and responding to agonist peptides (p) bound to MHC molecules in a sea of self pMHC molecules. Despite much work, understanding of the underlying mechanisms of distinguishing...

Full description

Bibliographic Details
Main Authors: Ganti, Raman S, Lo, Wan-Lin, McAffee, Darren B, Groves, Jay T, Weiss, Arthur, Chakraborty, Arup K
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2021
Online Access:https://hdl.handle.net/1721.1/135224