A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation fo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/135273 |
| _version_ | 1811091380385087488 |
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| author | Sinnott-Armstrong, N Sousa, IS Laber, S Rendina-Ruedy, E Nitter Dankel, SE Ferreira, T Mellgren, G Karasik, D Rivas, M Pritchard, J Guntur, AR Cox, RD Lindgren, CM Hauner, H Sallari, R Rosen, CJ Hsu, YH Lander, ES Kiel, DP Claussnitzer, M |
| author_facet | Sinnott-Armstrong, N Sousa, IS Laber, S Rendina-Ruedy, E Nitter Dankel, SE Ferreira, T Mellgren, G Karasik, D Rivas, M Pritchard, J Guntur, AR Cox, RD Lindgren, CM Hauner, H Sallari, R Rosen, CJ Hsu, YH Lander, ES Kiel, DP Claussnitzer, M |
| author_sort | Sinnott-Armstrong, N |
| collection | MIT |
| description | Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture. |
| first_indexed | 2024-09-23T15:01:30Z |
| format | Article |
| id | mit-1721.1/135273 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:01:30Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1352732021-10-28T03:29:05Z A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density Sinnott-Armstrong, N Sousa, IS Laber, S Rendina-Ruedy, E Nitter Dankel, SE Ferreira, T Mellgren, G Karasik, D Rivas, M Pritchard, J Guntur, AR Cox, RD Lindgren, CM Hauner, H Sallari, R Rosen, CJ Hsu, YH Lander, ES Kiel, DP Claussnitzer, M Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture. 2021-10-27T20:22:44Z 2021-10-27T20:22:44Z 2021-03-02 2021-07-20T18:04:37Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135273 en 10.1016/j.cmet.2021.01.001 Cell Metabolism Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Sinnott-Armstrong, N Sousa, IS Laber, S Rendina-Ruedy, E Nitter Dankel, SE Ferreira, T Mellgren, G Karasik, D Rivas, M Pritchard, J Guntur, AR Cox, RD Lindgren, CM Hauner, H Sallari, R Rosen, CJ Hsu, YH Lander, ES Kiel, DP Claussnitzer, M A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_full | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_fullStr | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_full_unstemmed | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_short | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_sort | regulatory variant at 3q21 1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| url | https://hdl.handle.net/1721.1/135273 |
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