Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

Show other versions (1)

© 2020, eLife Sciences Publications Ltd. All rights reserved. When ribosomes fail to complete normal translation, all cells have mechanisms to ensure degradation of the resulting partial proteins to safeguard proteome integrity. In E. coli and other eubacteria, the tmRNA system rescues stalled ribos...

Full description

Bibliographic Details
Main Authors:	Fei, Xue, Bell, Tristan A, Barkow, Sarah R, Baker, Tania A, Sauer, Robert T
Format:	Article
Language:	English
Published:	eLife Sciences Publications, Ltd 2021
Online Access:	https://hdl.handle.net/1721.1/135281

Similar Items

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates
by: Fei, Xue, et al.
Published: (2022)

ClpXP, an ATP-powered unfolding and protein-degradation machine
by: Baker, Tania, et al.
Published: (2014)

Polypeptide translocation by the AAA+ ClpXP protease machine
by: Barkow, Sarah R., et al.
Published: (2012)

Stepwise Unfolding of a β Barrel Protein by the AAA+ ClpXP Protease
by: Nager, Andrew Ross, et al.
Published: (2015)

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
by: Fei, Xue, et al.
Published: (2021)

Structure and function of ClpXP, a AAA+ proteolytic machine powered by probabilistic ATP hydrolysis
by: Sauer, Robert T, et al.
Published: (2023)

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
by: Fei, Xue, et al.
Published: (2022)

Multistep substrate binding and engagement by the AAA+ ClpXP protease
by: Saunders, Reuben A, et al.
Published: (2021)

Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine
by: Cordova, Juan Carlos, et al.
Published: (2017)

Mechanistic studies of the AAA+ molecular motor ClpXP
by: Barkow, Sarah Rebecca
Published: (2009)

Structural Principles of Substrate Recognition and Unfolding by the ClpAP and ClpXP AAA+ Proteases
by: Kim, Sora
Published: (2022)

Regulation of Antimycin Biosynthesis Is Controlled by the ClpXP Protease
by: Bilyk, Bohdan, et al.
Published: (2021)

Role of communication between subunits and enzymes in ClpXP-mediated substrate unfolding and degradation
by: Joshi, Shilpa Arun, 1975-
Published: (2005)

Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease
by: Shin, Yongdae, et al.
Published: (2010)

Substrate selection by the ClpXP protease : a tail of destruction
by: Flynn, Julia M., 1976-
Published: (2005)

Dissecting the steps of substrate processing by the energy-dependent protease ClpXP
by: Siddiqui, Samia M. (Siddiqui Mohammed), 1977-
Published: (2006)

Single molecule fluorescence spectroscopy of ClpXP-mediated substrate degradation
by: Shin, Yongdae
Published: (2010)

Temperature dependence of ssrA-tag mediated protein degradation
by: Purcell, Oliver, et al.
Published: (2012)

Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle
by: Sello, Jason K., et al.
Published: (2017)

NOA1, a Novel ClpXP Substrate, Takes an Unexpected Nuclear Detour Prior to Mitochondrial Import
by: Al-Furoukh, Natalie, et al.
Published: (2014)

Controlled degradation by ClpXP protease tunes the levels of the excision repair protein UvrA to the extent of DNA damage
by: Pruteanu, Mihaela, et al.
Published: (2014)

Identifying the requirement and mechanism of the dynamic yet kinetically stable ClpXP interface
by: Amor, Alvaro Jorge
Published: (2017)

The role of ClpXP-mediated proteolysis in resculpting the proteome after DNA damage
by: Neher, Saskia B. (Saskia Byerly)
Published: (2006)

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
by: Kim, Sora, et al.
Published: (2021)

The AAA+ ClpX machine unfolds a keystone subunit to remodel the Mu transpososome
by: Baker, Tania, et al.
Published: (2011)

Molecular basis of substrate selection by the N-end rule adaptor protein ClpS
by: Baker, Tania, et al.
Published: (2010)

Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding
by: Bell, Tristan Andrew, et al.
Published: (2020)

The Non-dominant AAA+ Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation
by: Kotamarthi, Hema Chandra, et al.
Published: (2021)

Energetics of substrate unfolding by ClpA
by: James, Melva Tonisha
Published: (2008)

Control of substrate gating and translocation into ClpP by channel residues and ClpX binding
by: Lee, Mary E., et al.
Published: (2012)

Hinge–Linker Elements in the AAA+ Protein Unfoldase ClpX Mediate Intersubunit Communication, Assembly, and Mechanical Activity
by: Bell, Tristan Andrew, et al.
Published: (2020)

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding
by: Kardon, Julia R, et al.
Published: (2021)

Crystal structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine
by: Glynn, Steven E., et al.
Published: (2012)

Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease
by: Zuromski, Kristin L, et al.
Published: (2021)

Roles of the ClpX IGF loops in ClpP association, dissociation, and protein degradation
by: Amor, Alvaro J., et al.
Published: (2022)

The Intrinsically Disordered N-terminal Extension of the ClpS Adaptor Reprograms Its Partner AAA + ClpAP Protease
by: Torres-Delgado, Amaris, et al.
Published: (2021)

Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates
by: Baker, Tania, et al.
Published: (2017)

The ClpS Adaptor Mediates Staged Delivery of N-End Rule Substrates to the AAA+ ClpAP Protease
by: Hou, Jennifer Y., et al.
Published: (2014)

Assaying the kinetics of protein denaturation catalyzed by AAA+ unfolding machines and proteases
by: Baytshtok, Vladimir, et al.
Published: (2015)

Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase
by: Schmitz, Karl Robert, et al.
Published: (2017)