Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration
© 2020 American Association for the Advancement of Science. All rights reserved. Neuronal circuits damaged or lost after injury can be regenerated in some adult organisms, but the mechanisms enabling this process are largely unknown. We used the planarian Schmidtea mediterranea to study visual syste...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
American Association for the Advancement of Science (AAAS)
2021
|
Online Access: | https://hdl.handle.net/1721.1/135325 |
_version_ | 1811094444585254912 |
---|---|
author | Scimone, M Lucila Atabay, Kutay D Fincher, Christopher T Bonneau, Ashley R Li, Dayan J Reddien, Peter W |
author_facet | Scimone, M Lucila Atabay, Kutay D Fincher, Christopher T Bonneau, Ashley R Li, Dayan J Reddien, Peter W |
author_sort | Scimone, M Lucila |
collection | MIT |
description | © 2020 American Association for the Advancement of Science. All rights reserved. Neuronal circuits damaged or lost after injury can be regenerated in some adult organisms, but the mechanisms enabling this process are largely unknown. We used the planarian Schmidtea mediterranea to study visual system regeneration after injury. We identify a rare population of muscle cells tightly associated with photoreceptor axons at stereotyped positions in both uninjured and regenerating animals. Together with a neuronal population, these cells promote de novo assembly of the visual system in diverse injury and eye transplantation contexts. These muscle guidepost-like cells are specified independently of eyes, and their position is defined by an extrinsic array of positional information cues. These findings provide a mechanism, involving adult formation of guidepost-like cells typically observed in embryos, for axon pattern restoration in regeneration. |
first_indexed | 2024-09-23T16:00:10Z |
format | Article |
id | mit-1721.1/135325 |
institution | Massachusetts Institute of Technology |
language | English |
last_indexed | 2024-09-23T16:00:10Z |
publishDate | 2021 |
publisher | American Association for the Advancement of Science (AAAS) |
record_format | dspace |
spelling | mit-1721.1/1353252021-10-28T03:14:49Z Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration Scimone, M Lucila Atabay, Kutay D Fincher, Christopher T Bonneau, Ashley R Li, Dayan J Reddien, Peter W © 2020 American Association for the Advancement of Science. All rights reserved. Neuronal circuits damaged or lost after injury can be regenerated in some adult organisms, but the mechanisms enabling this process are largely unknown. We used the planarian Schmidtea mediterranea to study visual system regeneration after injury. We identify a rare population of muscle cells tightly associated with photoreceptor axons at stereotyped positions in both uninjured and regenerating animals. Together with a neuronal population, these cells promote de novo assembly of the visual system in diverse injury and eye transplantation contexts. These muscle guidepost-like cells are specified independently of eyes, and their position is defined by an extrinsic array of positional information cues. These findings provide a mechanism, involving adult formation of guidepost-like cells typically observed in embryos, for axon pattern restoration in regeneration. 2021-10-27T20:22:58Z 2021-10-27T20:22:58Z 2020 2021-07-21T18:34:00Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135325 en 10.1126/SCIENCE.ABA3203 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
spellingShingle | Scimone, M Lucila Atabay, Kutay D Fincher, Christopher T Bonneau, Ashley R Li, Dayan J Reddien, Peter W Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration |
title | Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration |
title_full | Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration |
title_fullStr | Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration |
title_full_unstemmed | Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration |
title_short | Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration |
title_sort | muscle and neuronal guidepost like cells facilitate planarian visual system regeneration |
url | https://hdl.handle.net/1721.1/135325 |
work_keys_str_mv | AT scimonemlucila muscleandneuronalguidepostlikecellsfacilitateplanarianvisualsystemregeneration AT atabaykutayd muscleandneuronalguidepostlikecellsfacilitateplanarianvisualsystemregeneration AT fincherchristophert muscleandneuronalguidepostlikecellsfacilitateplanarianvisualsystemregeneration AT bonneauashleyr muscleandneuronalguidepostlikecellsfacilitateplanarianvisualsystemregeneration AT lidayanj muscleandneuronalguidepostlikecellsfacilitateplanarianvisualsystemregeneration AT reddienpeterw muscleandneuronalguidepostlikecellsfacilitateplanarianvisualsystemregeneration |