Engineering two-dimensional nanomaterials to enable structure-activity relationship studies in nanosafety research
© 2020 Elsevier B.V. Emerging, two-dimensional engineered nanomaterials (2DNMs) possess unique and diverse physical and chemical properties, such as extreme aspect ratios, adjustable electronic properties as well as functional lattice defects and surface chemistry which underpin their interactions w...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/135332 |
| _version_ | 1826199833451429888 |
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| author | Parviz, Dorsa Bitounis, Dimitrios Demokritou, Philip Strano, Michael |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Parviz, Dorsa Bitounis, Dimitrios Demokritou, Philip Strano, Michael |
| author_sort | Parviz, Dorsa |
| collection | MIT |
| description | © 2020 Elsevier B.V. Emerging, two-dimensional engineered nanomaterials (2DNMs) possess unique and diverse physical and chemical properties, such as extreme aspect ratios, adjustable electronic properties as well as functional lattice defects and surface chemistry which underpin their interactions with biological systems. This perspective highlights the need for structure activity relationship (SAR) studies for key properties of emerging graphene-related and inorganic 2DNMs upon prioritization based on their potential impact and trajectory for large-scale production and applications. Further, it is discussed how a synthesis platform of microbiologically sterile, size-sorted, “model” 2DNMs with precise structure would enable SAR toxicological studies and allow for the sustainable and safe translation of 2D nanotechnology to real-world applications. |
| first_indexed | 2024-09-23T11:26:29Z |
| format | Article |
| id | mit-1721.1/135332 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:26:29Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1353322023-03-01T14:52:12Z Engineering two-dimensional nanomaterials to enable structure-activity relationship studies in nanosafety research Parviz, Dorsa Bitounis, Dimitrios Demokritou, Philip Strano, Michael Massachusetts Institute of Technology. Department of Chemical Engineering © 2020 Elsevier B.V. Emerging, two-dimensional engineered nanomaterials (2DNMs) possess unique and diverse physical and chemical properties, such as extreme aspect ratios, adjustable electronic properties as well as functional lattice defects and surface chemistry which underpin their interactions with biological systems. This perspective highlights the need for structure activity relationship (SAR) studies for key properties of emerging graphene-related and inorganic 2DNMs upon prioritization based on their potential impact and trajectory for large-scale production and applications. Further, it is discussed how a synthesis platform of microbiologically sterile, size-sorted, “model” 2DNMs with precise structure would enable SAR toxicological studies and allow for the sustainable and safe translation of 2D nanotechnology to real-world applications. 2021-10-27T20:23:00Z 2021-10-27T20:23:00Z 2020 2021-06-15T17:05:15Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135332 en 10.1016/J.IMPACT.2020.100226 NanoImpact Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Parviz, Dorsa Bitounis, Dimitrios Demokritou, Philip Strano, Michael Engineering two-dimensional nanomaterials to enable structure-activity relationship studies in nanosafety research |
| title | Engineering two-dimensional nanomaterials to enable structure-activity relationship studies in nanosafety research |
| title_full | Engineering two-dimensional nanomaterials to enable structure-activity relationship studies in nanosafety research |
| title_fullStr | Engineering two-dimensional nanomaterials to enable structure-activity relationship studies in nanosafety research |
| title_full_unstemmed | Engineering two-dimensional nanomaterials to enable structure-activity relationship studies in nanosafety research |
| title_short | Engineering two-dimensional nanomaterials to enable structure-activity relationship studies in nanosafety research |
| title_sort | engineering two dimensional nanomaterials to enable structure activity relationship studies in nanosafety research |
| url | https://hdl.handle.net/1721.1/135332 |
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