Elasticizing tissues for reversible shape transformation and accelerated molecular labeling
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELAS...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/135336 |
| _version_ | 1811077665495449600 |
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| author | Ku, Taeyun Guan, Webster Evans, Nicholas B Sohn, Chang Ho Albanese, Alexandre Kim, Joon-Goon Frosch, Matthew P Chung, Kwanghun |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Ku, Taeyun Guan, Webster Evans, Nicholas B Sohn, Chang Ho Albanese, Alexandre Kim, Joon-Goon Frosch, Matthew P Chung, Kwanghun |
| author_sort | Ku, Taeyun |
| collection | MIT |
| description | © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs. |
| first_indexed | 2024-09-23T10:46:36Z |
| format | Article |
| id | mit-1721.1/135336 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:46:36Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1353362024-03-19T17:42:57Z Elasticizing tissues for reversible shape transformation and accelerated molecular labeling Ku, Taeyun Guan, Webster Evans, Nicholas B Sohn, Chang Ho Albanese, Alexandre Kim, Joon-Goon Frosch, Matthew P Chung, Kwanghun Massachusetts Institute of Technology. Institute for Medical Engineering & Science Picower Institute for Learning and Memory Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs. 2021-10-27T20:23:01Z 2021-10-27T20:23:01Z 2020 2021-06-08T18:21:48Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135336 en 10.1038/S41592-020-0823-Y Nature Methods Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Science and Business Media LLC PMC |
| spellingShingle | Ku, Taeyun Guan, Webster Evans, Nicholas B Sohn, Chang Ho Albanese, Alexandre Kim, Joon-Goon Frosch, Matthew P Chung, Kwanghun Elasticizing tissues for reversible shape transformation and accelerated molecular labeling |
| title | Elasticizing tissues for reversible shape transformation and accelerated molecular labeling |
| title_full | Elasticizing tissues for reversible shape transformation and accelerated molecular labeling |
| title_fullStr | Elasticizing tissues for reversible shape transformation and accelerated molecular labeling |
| title_full_unstemmed | Elasticizing tissues for reversible shape transformation and accelerated molecular labeling |
| title_short | Elasticizing tissues for reversible shape transformation and accelerated molecular labeling |
| title_sort | elasticizing tissues for reversible shape transformation and accelerated molecular labeling |
| url | https://hdl.handle.net/1721.1/135336 |
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