Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico
© 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. Two recent publications out of the same research laboratory report on structure-based in silico design of antibodies against viral targets without sequence disclosure. Cross-referencing the published data to p...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Informa UK Limited
2021
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| Online Access: | https://hdl.handle.net/1721.1/135375 |
| _version_ | 1826217689289326592 |
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| author | Vásquez, M Krauland, E Walker, L Wittrup, D Gerngross, T |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Vásquez, M Krauland, E Walker, L Wittrup, D Gerngross, T |
| author_sort | Vásquez, M |
| collection | MIT |
| description | © 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. Two recent publications out of the same research laboratory report on structure-based in silico design of antibodies against viral targets without sequence disclosure. Cross-referencing the published data to patent databases, we established the sequence identity of said computationally designed antibodies. In both cases, the antibodies align with high sequence identity to previously reported antibodies of the same specificity. This clear underlying sequence relationship, which is far closer than the antibody templates reported to seed the computational design, suggests an alternative origin of the computationally designed antibodies. The lack of both reproducible computational algorithms and of output sequences in the initial publications obscures the relationship to previously reported antibodies, and sows doubt as to the genesis narrative described therein. |
| first_indexed | 2024-09-23T17:07:36Z |
| format | Article |
| id | mit-1721.1/135375 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T17:07:36Z |
| publishDate | 2021 |
| publisher | Informa UK Limited |
| record_format | dspace |
| spelling | mit-1721.1/1353752023-02-22T17:11:34Z Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico Vásquez, M Krauland, E Walker, L Wittrup, D Gerngross, T Massachusetts Institute of Technology. Department of Biological Engineering © 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. Two recent publications out of the same research laboratory report on structure-based in silico design of antibodies against viral targets without sequence disclosure. Cross-referencing the published data to patent databases, we established the sequence identity of said computationally designed antibodies. In both cases, the antibodies align with high sequence identity to previously reported antibodies of the same specificity. This clear underlying sequence relationship, which is far closer than the antibody templates reported to seed the computational design, suggests an alternative origin of the computationally designed antibodies. The lack of both reproducible computational algorithms and of output sequences in the initial publications obscures the relationship to previously reported antibodies, and sows doubt as to the genesis narrative described therein. 2021-10-27T20:23:11Z 2021-10-27T20:23:11Z 2019-07-04 2021-06-17T18:02:10Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135375 en 10.1080/19420862.2019.1611172 mAbs Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Informa UK Limited Taylor & Francis |
| spellingShingle | Vásquez, M Krauland, E Walker, L Wittrup, D Gerngross, T Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico |
| title | Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico |
| title_full | Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico |
| title_fullStr | Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico |
| title_full_unstemmed | Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico |
| title_short | Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico |
| title_sort | connecting the sequence dots shedding light on the genesis of antibodies reported to be designed in silico |
| url | https://hdl.handle.net/1721.1/135375 |
| work_keys_str_mv | AT vasquezm connectingthesequencedotssheddinglightonthegenesisofantibodiesreportedtobedesignedinsilico AT kraulande connectingthesequencedotssheddinglightonthegenesisofantibodiesreportedtobedesignedinsilico AT walkerl connectingthesequencedotssheddinglightonthegenesisofantibodiesreportedtobedesignedinsilico AT wittrupd connectingthesequencedotssheddinglightonthegenesisofantibodiesreportedtobedesignedinsilico AT gerngrosst connectingthesequencedotssheddinglightonthegenesisofantibodiesreportedtobedesignedinsilico |