Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells

Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells

Copyright © 2020 Massachusetts Medical Society. Many mitochondrial diseases are caused by mutations in mitochondrial DNA (mtDNA). Patients’ cells contain a mixture of mutant and nonmutant mtDNA (a phenomenon called heteroplasmy). The proportion of mutant mtDNA varies across patients and among tissue...

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Bibliographic Details
Main Authors: Walker, Melissa A, Lareau, Caleb A, Ludwig, Leif S, Karaa, Amel, Sankaran, Vijay G, Regev, Aviv, Mootha, Vamsi K
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Massachusetts Medical Society 2021
Online Access:https://hdl.handle.net/1721.1/135482

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