Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells

Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells

Copyright © 2020 Massachusetts Medical Society. Many mitochondrial diseases are caused by mutations in mitochondrial DNA (mtDNA). Patients’ cells contain a mixture of mutant and nonmutant mtDNA (a phenomenon called heteroplasmy). The proportion of mutant mtDNA varies across patients and among tissue...

Full description

Bibliographic Details
Main Authors:	Walker, Melissa A, Lareau, Caleb A, Ludwig, Leif S, Karaa, Amel, Sankaran, Vijay G, Regev, Aviv, Mootha, Vamsi K
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	English
Published:	Massachusetts Medical Society 2021
Online Access:	https://hdl.handle.net/1721.1/135482

Similar Items

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling
by: Lareau, Caleb A, et al.
Published: (2021)

Correcting for purifying selection: an improved human mitochondrial molecular clock
by: Soares, P, et al.
Published: (2009)

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics
by: Regev, Aviv
Published: (2020)

Mitochondrial dysfunction remodels one-carbon metabolism in human cells
by: Bao, Xiaoyan Robert, et al.
Published: (2016)

Pathogenic mtDNA mutations causing mitochondrial myopathy: the need for muscle biopsy
by: Hardy, S, et al.
Published: (2016)

Cellular gels. Purifying and mapping long DNA molecules.
by: Dear, P, et al.
Published: (1991)

Sequence-directed DNA translocation by purified FtsK.
by: Pease, P, et al.
Published: (2005)

The purified recombinant precursor of rat mitochondrial dimethylglycine dehydrogenase binds FAD via an autocatalytic reaction.
by: Brizio, C, et al.
Published: (2008)

Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging
by: Udeshi, Namrata D., et al.
Published: (2017)

Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans
by: Wei, W, et al.
Published: (2020)

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation
by: Udeshi, Namrata D, et al.
Published: (2017)

A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells
by: Shaham, Oded, et al.
Published: (2011)

SPFL: a self-purified federated learning method against poisoning attacks
by: Liu, Zizhen, et al.
Published: (2024)

Collated mutations in mitochondrial DNA (mtDNA) depletion syndrome (excluding the mitochondrial gamma polymerase, POLG1).
by: Poulton, J, et al.
Published: (2009)

Amplification of mitochondrial DNA in CGL in transformation.
by: Fidler, C, et al.
Published: (1996)

Biparental inheritance of mitochondrial DNA revisited
by: Pagnamenta, AT, et al.
Published: (2021)

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
by: Wu, Chuan, et al.
Published: (2013)

Exploring mitochondrial DNA variation in the Italian Peninsula
by: Brisighelli, F, et al.
Published: (2008)

DNA polymerase theta purified from human cells is a high-fidelity enzyme.
by: Maga, G, et al.
Published: (2002)

Reply: Mitochondrial DNA Quantification-the devil in the detail
by: Wells, D, et al.
Published: (2017)

Amplification of mitochondrial DNA in acute myeloid leukaemia.
by: Boultwood, J, et al.
Published: (1996)

Antigenic potential of a recombinant polyvalent DNA vaccine against pathogenic leptospiral infection
by: Zakaria, Zunita, et al.
Published: (2019)

Towards 'purifying' the understanding of Allah
by: Abd Razak, Dzulkifli
Published: (2008)

JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia
by: Rosenberg, Jacob M, et al.
Published: (2023)

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans
by: Calvo, Sarah E., et al.
Published: (2009)

Biochemical characterizations of Escherichia coli DnaK and DnaK mutant proteins purified from ndk deficient cells
by: Barthel, Thomas K. (Thomas Kreider), 1966-
Published: (2014)

Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA.
by: Conway, D, et al.
Published: (2000)

Vaccines against gut pathogens
by: Mastroeni, P, et al.
Published: (1999)

Vaccines against gut pathogens.
by: Mastroeni, P, et al.
Published: (1999)

AMPLIFICATION OF MITOCHONDRIAL-DNA IN ACUTE MYELOID-LEUKEMIA
by: Boultwood, J, et al.
Published: (1994)

Transcription Regulates Biased Mitochondrial DNA Inheritance
by: Corbi, Daniel R.
Published: (2022)

Nuclear transfer to prevent mitochondrial DNA diseases.
by: Poulton, J, et al.
Published: (2006)

Mitochondrial DNA of human-mouse cell hybrids.
by: Clayton, D, et al.
Published: (1971)

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling
by: Plovanich, Molly, et al.
Published: (2013)

Development of a multivalent DNA vaccine against pathogenic leptospiral infection in laboratory animal model
by: Bashiru, Garba
Published: (2017)

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features
by: Ray, John P, et al.
Published: (2021)

Reconstructing ancient mitochondrial DNA links between Africa and Europe.
by: Cerezo, M, et al.
Published: (2012)

Purified lipase, methods of modification and applications
by: Raja Abdul Rahman, Raja Noor Zaliha, et al.
Published: (2011)

Germline selection shapes human mitochondrial DNA diversity
by: Wei, W, et al.
Published: (2019)

Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances
by: Ashley, N, et al.
Published: (2007)