Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1

Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1

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Enhanced stemness in colorectal cancer has been reported and it contributes to aggressive progression, but the underlying mechanisms remain unclear. Here we report a Wnt ligand, Dickkopf-2 (DKK2) is essential for developing colorectal cancer stemness. Genetic depletion of DKK2 in intestinal epitheli...

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Bibliographic Details
Main Authors:	Shin, Jae Hun, Jeong, Jaekwang, Choi, Jungmin, Lim, Jaechul, Dinesh, Ravi K, Braverman, Jonathan, Hong, Jun Young, Maher, Stephen E, Amezcua Vesely, Maria C, Kim, WonJu, Koo, Ja-Hyun, Tang, Wenwen, Wu, Dianqing, Blackburn, Holly N, Xicola, Rosa M, Llor, Xavier, Yilmaz, Omer, Choi, Je-Min, Bothwell, Alfred LM
Format:	Article
Language:	English
Published:	Elsevier BV 2021
Online Access:	https://hdl.handle.net/1721.1/135553

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