Neuron class-specific responses govern adaptive myelin remodeling in the neocortex
© 2020 American Association for the Advancement of Science. All rights reserved. Myelin plasticity is critical for neurological function, including learning and memory. However, it is unknown whether this plasticity reflects uniform changes across all neuronal subtypes, or whether myelin dynamics va...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2021
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| Online Access: | https://hdl.handle.net/1721.1/135566 |
| _version_ | 1826192435002212352 |
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| author | Yang, SM Michel, K Jokhi, V Nedivi, E Arlotta, P |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Yang, SM Michel, K Jokhi, V Nedivi, E Arlotta, P |
| author_sort | Yang, SM |
| collection | MIT |
| description | © 2020 American Association for the Advancement of Science. All rights reserved. Myelin plasticity is critical for neurological function, including learning and memory. However, it is unknown whether this plasticity reflects uniform changes across all neuronal subtypes, or whether myelin dynamics vary between neuronal classes to enable fine-tuning of adaptive circuit responses. We performed in vivo two-photon imaging of myelin sheaths along single axons of excitatory callosal neurons and inhibitory parvalbumin-expressing interneurons in adult mouse visual cortex. We found that both neuron types show homeostatic myelin remodeling under normal vision. However, monocular deprivation results in adaptive myelin remodeling only in parvalbumin-expressing interneurons. An initial increase in elongation of myelin segments is followed by contraction of a separate cohort of segments. This data indicates that distinct classes of neurons individualize remodeling of their myelination profiles to diversify circuit tuning in response to sensory experience. |
| first_indexed | 2024-09-23T09:12:50Z |
| format | Article |
| id | mit-1721.1/135566 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:12:50Z |
| publishDate | 2021 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1355662023-03-01T21:16:32Z Neuron class-specific responses govern adaptive myelin remodeling in the neocortex Yang, SM Michel, K Jokhi, V Nedivi, E Arlotta, P Picower Institute for Learning and Memory Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences © 2020 American Association for the Advancement of Science. All rights reserved. Myelin plasticity is critical for neurological function, including learning and memory. However, it is unknown whether this plasticity reflects uniform changes across all neuronal subtypes, or whether myelin dynamics vary between neuronal classes to enable fine-tuning of adaptive circuit responses. We performed in vivo two-photon imaging of myelin sheaths along single axons of excitatory callosal neurons and inhibitory parvalbumin-expressing interneurons in adult mouse visual cortex. We found that both neuron types show homeostatic myelin remodeling under normal vision. However, monocular deprivation results in adaptive myelin remodeling only in parvalbumin-expressing interneurons. An initial increase in elongation of myelin segments is followed by contraction of a separate cohort of segments. This data indicates that distinct classes of neurons individualize remodeling of their myelination profiles to diversify circuit tuning in response to sensory experience. 2021-10-27T20:24:03Z 2021-10-27T20:24:03Z 2021-12-18 2021-07-07T16:21:06Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135566 en 10.1126/science.abd2109 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Yang, SM Michel, K Jokhi, V Nedivi, E Arlotta, P Neuron class-specific responses govern adaptive myelin remodeling in the neocortex |
| title | Neuron class-specific responses govern adaptive myelin remodeling in the neocortex |
| title_full | Neuron class-specific responses govern adaptive myelin remodeling in the neocortex |
| title_fullStr | Neuron class-specific responses govern adaptive myelin remodeling in the neocortex |
| title_full_unstemmed | Neuron class-specific responses govern adaptive myelin remodeling in the neocortex |
| title_short | Neuron class-specific responses govern adaptive myelin remodeling in the neocortex |
| title_sort | neuron class specific responses govern adaptive myelin remodeling in the neocortex |
| url | https://hdl.handle.net/1721.1/135566 |
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