me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline
<jats:title>ABSTRACT</jats:title> <jats:p>Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. Differentiated/differentiating cells can revert back to a stem cell identity vi...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2021
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| Online Access: | https://hdl.handle.net/1721.1/135650 |
| _version_ | 1826206203945943040 |
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| author | Jensen, Lindy Venkei, Zsolt G Watase, George J Bisai, Bitarka Pletcher, Scott Lee, Cheng-Yu Yamashita, Yukiko M |
| author2 | Whitehead Institute for Biomedical Research |
| author_facet | Whitehead Institute for Biomedical Research Jensen, Lindy Venkei, Zsolt G Watase, George J Bisai, Bitarka Pletcher, Scott Lee, Cheng-Yu Yamashita, Yukiko M |
| author_sort | Jensen, Lindy |
| collection | MIT |
| description | <jats:title>ABSTRACT</jats:title>
<jats:p>Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. Differentiated/differentiating cells can revert back to a stem cell identity via dedifferentiation to help maintain the stem cell pool beyond the lifetime of individual stem cells. Although dedifferentiation is important for maintaining the stem cell population, it is speculated that it underlies tumorigenesis. Therefore, this process must be tightly controlled. Here, we show that a translational regulator, me31B, plays a critical role in preventing excess dedifferentiation in the Drosophila male germline: in the absence of me31B, spermatogonia dedifferentiate into germline stem cells (GSCs) at a dramatically elevated frequency. Our results show that the excess dedifferentiation is likely due to misregulation of nos, a key regulator of germ cell identity and GSC maintenance. Taken together, our data reveal negative regulation of dedifferentiation to balance stem cell maintenance with differentiation.</jats:p> |
| first_indexed | 2024-09-23T13:25:44Z |
| format | Article |
| id | mit-1721.1/135650 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:25:44Z |
| publishDate | 2021 |
| publisher | The Company of Biologists |
| record_format | dspace |
| spelling | mit-1721.1/1356502023-09-14T19:50:11Z me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline Jensen, Lindy Venkei, Zsolt G Watase, George J Bisai, Bitarka Pletcher, Scott Lee, Cheng-Yu Yamashita, Yukiko M Whitehead Institute for Biomedical Research Massachusetts Institute of Technology. Department of Biology Howard Hughes Medical Institute <jats:title>ABSTRACT</jats:title> <jats:p>Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. Differentiated/differentiating cells can revert back to a stem cell identity via dedifferentiation to help maintain the stem cell pool beyond the lifetime of individual stem cells. Although dedifferentiation is important for maintaining the stem cell population, it is speculated that it underlies tumorigenesis. Therefore, this process must be tightly controlled. Here, we show that a translational regulator, me31B, plays a critical role in preventing excess dedifferentiation in the Drosophila male germline: in the absence of me31B, spermatogonia dedifferentiate into germline stem cells (GSCs) at a dramatically elevated frequency. Our results show that the excess dedifferentiation is likely due to misregulation of nos, a key regulator of germ cell identity and GSC maintenance. Taken together, our data reveal negative regulation of dedifferentiation to balance stem cell maintenance with differentiation.</jats:p> 2021-10-27T20:24:27Z 2021-10-27T20:24:27Z 2021 2021-08-04T16:36:34Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135650 en 10.1242/jcs.258757 Journal of Cell Science Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf The Company of Biologists Journal of Cell Science |
| spellingShingle | Jensen, Lindy Venkei, Zsolt G Watase, George J Bisai, Bitarka Pletcher, Scott Lee, Cheng-Yu Yamashita, Yukiko M me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline |
| title | me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline |
| title_full | me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline |
| title_fullStr | me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline |
| title_full_unstemmed | me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline |
| title_short | me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline |
| title_sort | me31b regulates stem cell homeostasis by preventing excess dedifferentiation in the drosophila male germline |
| url | https://hdl.handle.net/1721.1/135650 |
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