High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing intestinal stem cell (ISC) numbers, proliferation, and function. Although PPAR (peroxisome proliferator-activated recep...

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Bibliographic Details
Main Authors:	Mana, Miyeko D, Hussey, Amanda M, Tzouanas, Constantine N, Imada, Shinya, Barrera Millan, Yesenia, Bahceci, Dorukhan, Saiz, Dominic R, Webb, Anna T, Lewis, Caroline A, Carmeliet, Peter, Mihaylova, Maria M, Shalek, Alex K, Yilmaz, Ömer H
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	English
Published:	Elsevier BV 2021
Online Access:	https://hdl.handle.net/1721.1/135658

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