Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection
© 2020 Background: Colombians in coastal Tumaco have a lower incidence of Helicobacter pylori-associated gastric cancer compared to individuals from Tuquerres in the high Andes. This is despite nearly universal prevalence of H. pylori infection and chronic gastritis. Methods: H. pylori infection was...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/135685 |
| _version_ | 1826201122501558272 |
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| author | Whary, Mark T Avenia, Jose M Restrepo Bravo, Luis E Lofgren, Jennifer L Lertpiriyapong, Kvin Mera-Giler, Robertino Piazuelo, M Blanca Correa, Pelayo Peek, Richard M Wilson, Keith T Fox, James G |
| author_facet | Whary, Mark T Avenia, Jose M Restrepo Bravo, Luis E Lofgren, Jennifer L Lertpiriyapong, Kvin Mera-Giler, Robertino Piazuelo, M Blanca Correa, Pelayo Peek, Richard M Wilson, Keith T Fox, James G |
| author_sort | Whary, Mark T |
| collection | MIT |
| description | © 2020 Background: Colombians in coastal Tumaco have a lower incidence of Helicobacter pylori-associated gastric cancer compared to individuals from Tuquerres in the high Andes. This is despite nearly universal prevalence of H. pylori infection and chronic gastritis. Methods: H. pylori infection was confirmed by Steiner stain and serology using African and European-origin strains. Gastric histology and serum inflammatory biomarkers in dyspeptic Tumaco or Tuquerres patients were evaluated to predict progression of gastric lesions. Results: H. pylori infection was nearly universal by Steiner stain and serology. IgG response to European-origin H. pylori strains were greater than African-origin. High gastric cancer-risk Tuquerres patients, compared to low-risk Tumaco, had significant odds ratios for lesion progression associated with serum IL-5, trefoil factor 3 (TFF3), and low pepsinogen I/II ratio. Sensitivity and specificity for these parameters was 63.8% and 67.9%, respectively, with correctly classifying patients at 66.7%. Most odds ratios for 26 other biomarkers were significant for the town of residency, indicating an environmental impact on Tumaco patients associated with decreased lesion progression. Conclusion: An IL-5 association with progression of gastric lesions is novel and could be evaluated in addition to TFF3 and pepsinogen I/II ratio as a non-invasive prognostic screen. Results suggest Tumaco patients were exposed to infectious diseases beyond H. pylori such as the documented high incidence of helminthiasis and toxoplasmosis. Impact: Results support a prior recommendation to evaluate TFF3 and pepsinogen I/II together to predict aggressive gastric histology. Our data indicate IL-5 should be further evaluated as prognostic parameter. |
| first_indexed | 2024-09-23T11:46:34Z |
| format | Article |
| id | mit-1721.1/135685 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:46:34Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1356852021-10-28T04:11:20Z Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection Whary, Mark T Avenia, Jose M Restrepo Bravo, Luis E Lofgren, Jennifer L Lertpiriyapong, Kvin Mera-Giler, Robertino Piazuelo, M Blanca Correa, Pelayo Peek, Richard M Wilson, Keith T Fox, James G © 2020 Background: Colombians in coastal Tumaco have a lower incidence of Helicobacter pylori-associated gastric cancer compared to individuals from Tuquerres in the high Andes. This is despite nearly universal prevalence of H. pylori infection and chronic gastritis. Methods: H. pylori infection was confirmed by Steiner stain and serology using African and European-origin strains. Gastric histology and serum inflammatory biomarkers in dyspeptic Tumaco or Tuquerres patients were evaluated to predict progression of gastric lesions. Results: H. pylori infection was nearly universal by Steiner stain and serology. IgG response to European-origin H. pylori strains were greater than African-origin. High gastric cancer-risk Tuquerres patients, compared to low-risk Tumaco, had significant odds ratios for lesion progression associated with serum IL-5, trefoil factor 3 (TFF3), and low pepsinogen I/II ratio. Sensitivity and specificity for these parameters was 63.8% and 67.9%, respectively, with correctly classifying patients at 66.7%. Most odds ratios for 26 other biomarkers were significant for the town of residency, indicating an environmental impact on Tumaco patients associated with decreased lesion progression. Conclusion: An IL-5 association with progression of gastric lesions is novel and could be evaluated in addition to TFF3 and pepsinogen I/II ratio as a non-invasive prognostic screen. Results suggest Tumaco patients were exposed to infectious diseases beyond H. pylori such as the documented high incidence of helminthiasis and toxoplasmosis. Impact: Results support a prior recommendation to evaluate TFF3 and pepsinogen I/II together to predict aggressive gastric histology. Our data indicate IL-5 should be further evaluated as prognostic parameter. 2021-10-27T20:28:46Z 2021-10-27T20:28:46Z 2020 2021-09-13T14:51:08Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135685 en 10.1016/J.CANEP.2020.101726 Cancer Epidemiology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Whary, Mark T Avenia, Jose M Restrepo Bravo, Luis E Lofgren, Jennifer L Lertpiriyapong, Kvin Mera-Giler, Robertino Piazuelo, M Blanca Correa, Pelayo Peek, Richard M Wilson, Keith T Fox, James G Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection |
| title | Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection |
| title_full | Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection |
| title_fullStr | Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection |
| title_full_unstemmed | Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection |
| title_short | Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection |
| title_sort | contrasting serum biomarker profiles in two colombian populations with different risks for progression of premalignant gastric lesions during chronic helicobacter pylori infection |
| url | https://hdl.handle.net/1721.1/135685 |
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