Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions

Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions

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<jats:p> T-cell identity is established by the expression of a clonotypic T-cell receptor (TCR), generated by somatic rearrangement of TCRα and β genes. The properties of the TCR determine both the degree of self-reactivity and the repertoire of antigens that can be recognized. For...

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Bibliographic Details
Main Authors: Swee, Lee Kim, Tan, Zhen Wei, Sanecka, Anna, Yoshida, Nagisa, Patel, Harshil, Grotenbreg, Gijsbert, Frickel, Eva-Maria, Ploegh, Hidde L
Format: Article
Language:English
Published: The Royal Society 2021
Online Access:https://hdl.handle.net/1721.1/135734

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