Evolution of macromolecular complexity in drug delivery systems
© 2017 Macmillan Publishers Limited. Designing therapeutics is a process with many challenges. Even if the first hurdle-designing a drug that modulates the action of a particular biological target in vitro-is overcome, selective delivery to that target in vivo presents a major barrier. Side-effects...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/135762 |
| _version_ | 1810977986764079104 |
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| author | Kakkar, Ashok Traverso, Giovanni Farokhzad, Omid C Weissleder, Ralph Langer, Robert |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Kakkar, Ashok Traverso, Giovanni Farokhzad, Omid C Weissleder, Ralph Langer, Robert |
| author_sort | Kakkar, Ashok |
| collection | MIT |
| description | © 2017 Macmillan Publishers Limited. Designing therapeutics is a process with many challenges. Even if the first hurdle-designing a drug that modulates the action of a particular biological target in vitro-is overcome, selective delivery to that target in vivo presents a major barrier. Side-effects can, in many cases, result from the need to use higher doses without targeted delivery. However, the established use of macromolecules to encapsulate or conjugate drugs can provide improved delivery, and stands to enable better therapeutic outcomes. In this Review, we discuss how drug delivery approaches have evolved alongside our ability to prepare increasingly complex macromolecular architectures. We examine how this increased complexity has overcome the challenges of drug delivery and discuss its potential for fulfilling unmet needs in nanomedicine. |
| first_indexed | 2024-09-23T09:19:53Z |
| format | Article |
| id | mit-1721.1/135762 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:19:53Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1357622023-10-05T19:59:04Z Evolution of macromolecular complexity in drug delivery systems Kakkar, Ashok Traverso, Giovanni Farokhzad, Omid C Weissleder, Ralph Langer, Robert Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT © 2017 Macmillan Publishers Limited. Designing therapeutics is a process with many challenges. Even if the first hurdle-designing a drug that modulates the action of a particular biological target in vitro-is overcome, selective delivery to that target in vivo presents a major barrier. Side-effects can, in many cases, result from the need to use higher doses without targeted delivery. However, the established use of macromolecules to encapsulate or conjugate drugs can provide improved delivery, and stands to enable better therapeutic outcomes. In this Review, we discuss how drug delivery approaches have evolved alongside our ability to prepare increasingly complex macromolecular architectures. We examine how this increased complexity has overcome the challenges of drug delivery and discuss its potential for fulfilling unmet needs in nanomedicine. 2021-10-27T20:29:11Z 2021-10-27T20:29:11Z 2017 2019-09-06T18:41:47Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/135762 en 10.1038/S41570-017-0063 Nature Reviews Chemistry Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Science and Business Media LLC PMC |
| spellingShingle | Kakkar, Ashok Traverso, Giovanni Farokhzad, Omid C Weissleder, Ralph Langer, Robert Evolution of macromolecular complexity in drug delivery systems |
| title | Evolution of macromolecular complexity in drug delivery systems |
| title_full | Evolution of macromolecular complexity in drug delivery systems |
| title_fullStr | Evolution of macromolecular complexity in drug delivery systems |
| title_full_unstemmed | Evolution of macromolecular complexity in drug delivery systems |
| title_short | Evolution of macromolecular complexity in drug delivery systems |
| title_sort | evolution of macromolecular complexity in drug delivery systems |
| url | https://hdl.handle.net/1721.1/135762 |
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